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  • Rabbit Anti-EIF2B4 Recombinant Antibody (EG1062)

Rabbit Anti-EIF2B4 Recombinant Antibody (EG1062) (CBMAB-EN1253-LY)

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Basic Information

Host Animal
Rabbit
Clone
EG1062
Application
WB: 1:500~1:1000 ELISA: 1:1000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human EIF2B4.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Eukaryotic Translation Initiation Factor 2B Subunit Delta
Introduction
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human8890
Mouse13667
Rat117019
UniProt ID
HumanQ9UI10
MouseQ61749
RatQ63186
Alternative Names
Eukaryotic Translation Initiation Factor 2B Subunit Delta; Eukaryotic Translation Initiation Factor 2B, Subunit 4 Delta, 67kDa; EIF-2B GDP-GTP Exchange Factor Subunit Delta; Eukaryotic Translation Initiation Factor 2B, Subunit 4 (Delta, 67kD); Eukaryotic Translation Initiation Factor 2B Subunit 4 Delta; Translation Initiation Factor EIF-2B Subunit Delta;
Research Area
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Biological Process
Myelination Source: UniProtKB
Oligodendrocyte development Source: UniProtKB
Ovarian follicle development Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of translation Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB
Cellular Location
Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2B complex
Involvement in disease
Leukodystrophy with vanishing white matter (VWM):
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.

Tian, Y., Liu, Q., Zhou, Y., Chen, X. Y., Pan, Y., Xu, H., & Yang, Z. (2022). Identification of a Novel Heterozygous Mutation in the EIF2B4 Gene Associated With Vanishing White Matter Disease. Front. Bioeng. Biotechnol. 10: 901452. doi: 10.3389/fbioe. 2022.901452. Frontiers in Bioengineering and Biotechnology| www. frontiersin. org, 10.

Hettiaracchchi, D., Neththikumara, N., Pathirana, B. A. P. S., Padeniya, A., & Dissanayake, V. H. W. (2018). A novel mutation in the EIF2B4 gene associated with leukoencephalopathy with vanishing white matter. Case Reports in Pediatrics, 2018.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-EIF2B4 Recombinant Antibody (EG1062) (CAT#: V2LY-0425-LY1663)

Related Products

Mouse Anti-EIF2B4 Recombinant Antibody (EG1062) (CAT#: V2LY-0425-LY1663)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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