Mouse Anti-EIF2B4 Recombinant Antibody (EG1062) (V2LY-0425-LY1663)
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(B) (i) Cells express dispersed eIF2B or localized eIF2B (eIF2B bodies). (ii) Mean percentage of cells displaying dispersed eIF2B or localized eIF2B in a population of 100 transfected cells (mean ± SEM; N = 4; ∗∗∗∗p ≤ 0.001, ∗∗∗p ≤ 0.001 according to two-way ANOVA).
(C) (i) eIF2B bodies were categorized as small bodies (<1μ2) and large bodies (≥1μ2). (ii) Within the transfected cells exhibiting localized eIF2B, the mean percentage of small and large eIF2B bodies in a population of 50 cells (mean ± SEM; N = 3; ∗∗∗∗p ≤ 0.001, ∗∗∗p ≤ 0.001, ns: non-significant according to two-way ANOVA).
(D) (i) Confocal images of SH-SY5Y, U373 and MO3.13 expressing eIF2Bε-mGFP and immunolabelled with primary anti-eIF2Bα, anti-eIF2Bβ, anti-eIF2Bδ and anti-eIF2Bγ. Scale bar: 10 μm. (ii) Mean percentage of small (top panel) and large bodies (bottom panel) co-localizing with eIF2B(α-γ) subunits of at least 30 cells per repeat (mean ± SEM; N = 3; ∗∗p ≤ 0.01, ∗p < 0.05 according to one-way ANOVA). ...View More
Basic Information
| Application | Note |
| ELISA | 1:100-1:1,000 |
| WB | 1:100-1:1,000 |
| IP | 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
| IF(ICC) | 1:50-1:500 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Oligodendrocyte development Source: UniProtKB
Ovarian follicle development Source: UniProtKB
Regulation of catalytic activity Source: GOC
Regulation of translation Source: UniProtKB
Response to glucose Source: UniProtKB
Response to heat Source: UniProtKB
Response to peptide hormone Source: UniProtKB
T cell receptor signaling pathway Source: UniProtKB
Translational initiation Source: UniProtKB
A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Alternative Versions
Rabbit Anti-EIF2B4 Recombinant Antibody (EG1062) (CAT#: CBMAB-EN1253-LY)
Related Products
Rabbit Anti-EIF2B4 Recombinant Antibody (EG1062) (CAT#: CBMAB-EN1253-LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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