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Rabbit Anti-ELF1 Recombinant Antibody (EG1084) (CBMAB-EN1280-LY)

The product is antibody recognizes ELF1. The antibody EG1084 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000.
See all ELF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1084
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human ELF1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
E74 Like ETS Transcription Factor 1
Introduction
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Entrez Gene ID
1997
UniProt ID
P32519
Alternative Names
E74 Like ETS Transcription Factor 1; E74-Like Factor 1 (Ets Domain Transcription Factor); ETS-Related Transcription Factor Elf-1; E74-Like Factor 1; EFTUD1; RIA1;
Research Area
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
Biological Process
Cell differentiation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Qiao, C., Qiao, T., Yang, S., Liu, L., & Zheng, M. (2022). SNHG17/miR-384/ELF1 axis promotes cell growth by transcriptional regulation of CTNNB1 to activate Wnt/β-catenin pathway in oral squamous cell carcinoma. Cancer Gene Therapy, 29(1), 122-132.

Liu, H., Liu, L., Liu, Q., He, F., & Zhu, H. (2022). LncRNA HOXD-AS1 affects proliferation and apoptosis of cervical cancer cells by promoting FRRS1 expression via transcription factor ELF1. Cell Cycle, 21(4), 416-426.

Hu, M., Li, H., Xie, H., Fan, M., Wang, J., Zhang, N., ... & Che, S. (2021). ELF1 transcription factor enhances the Progression of glioma via ATF5 promoter. ACS Chemical Neuroscience, 12(7), 1252-1261.

Xu, J., Chong, J., & Wang, D. (2021). Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures. Nucleic acids research, 49(9), 4944-4953.

Cheng, M., Zeng, Y., Zhang, T., Xu, M., Li, Z., & Wu, Y. (2021). Transcription factor ELF1 activates MEIS1 transcription and then regulates the GFI1/FBW7 axis to promote the development of glioma. Molecular Therapy-Nucleic Acids, 23, 418-430.

Wang, L. (2021). ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3. Journal of bone oncology, 26, 100335.

Wang, M., Yang, C., Liu, X., Zheng, J., Xue, Y., Ruan, X., ... & Liu, Y. (2020). An upstream open reading frame regulates vasculogenic mimicry of glioma via ZNRD1‐AS1/miR‐499a‐5p/ELF1/EMI1 pathway. Journal of cellular and molecular medicine, 24(11), 6120-6136.

Wang, L., Tang, D., Wu, T., & Sun, F. (2020). ELF1‐mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression. Cancer Medicine, 9(6), 2160-2170.

Ehara, H., & Sekine, S. I. (2018). Architecture of the RNA polymerase II elongation complex: new insights into Spt4/5 and Elf1. Transcription, 9(5), 286-291.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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