Mouse Anti-ELMO2 Recombinant Antibody (2E5) (V2LY-0825-LY100)

Name: Mouse Anti-ELMO2 Recombinant Antibody (2E5)
SKU: V2LY-0825-LY100
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E5

Application

ELISA

Immunogen

ELMO2 (aa 89-188) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

engulfment and cell motility 2

Entrez Gene ID

63916

UniProt ID

Q96JJ3

Research Area

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Biological Process

Actin filament organization Source: GO_Central
Apoptotic process Source: UniProtKB-KW
Cell-cell adhesion Source: InterPro
Cell chemotaxis Source: UniProtKB
Cell motility Source: GO_Central
Phagocytosis Source: UniProtKB-KW

Cellular Location

Cytoplasm; Cytosol; Membrane

Involvement in disease

Vascular malformation, primary intraosseous (VMOS):
A rare malformation characterized by non-neoplastic severe expansions of blood vessels, usually seen in the vertebral column and in the skull. The most commonly affected bones in the skull are the mandible and the maxilla, and life-threatening bleeding after a simple tooth extraction is frequently observed. Inheritance is autosomal recessive.

Rajiv, D. (2022). Characterization of the ELMO2 Protein that Mediates Cell Adhesion in Arabidopsis thaliana.

Wang, Y., Li, H., & Li, F. (2020). ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis. PeerJ, 8, e8910.

Vargel, I., Calis, M., Canter, H. I., & Cil, B. E. (2019). Clinical and Molecular Study of ELMO-2–Related Massive Intraosseous Vascular Malformations: Lessons Learned From 25 Years of Follow-up. Annals of Plastic Surgery, 83(3), 293-299.

Weng, Z., Situ, C., Lin, L., Wu, Z., Zhu, J., & Zhang, R. (2019). Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nature communications, 10(1), 1-10.

Li, W., Xiong, X., Abdalla, A., Alejo, S., Zhu, L., Lu, F., & Sun, H. (2018). HGF-induced formation of the MET–AXL–ELMO2–DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion. Journal of Biological Chemistry, 293(40), 15397-15418.

Mehawej, C., Hoischen, A., Farah, R. A., Marey, I., David, M., Stora, S., ... & Mégarbané, A. (2018). Homozygous mutation in ELMO2 may cause Ramon syndrome. Clinical Genetics, 93(3), 703-706.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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