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Mouse Anti-ENPP3 (AA 602-700) Recombinant Antibody (CBFYE-0892) (CBMAB-E1357-FY)

This product is mouse antibody that recognizes ENPP3. The antibody CBFYE-0892 can be used for immunoassay techniques such as: ELISA, WB.
See all ENPP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0892
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa602-700 from human ENPP3 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 602-700

Target

Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 3
Introduction
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
Entrez Gene ID
5169
UniProt ID
O14638
Alternative Names
Ectonucleotide Pyrophosphatase/Phosphodiesterase 3; Phosphodiesterase I/Nucleotide Pyrophosphatase 3; PD-IBETA; PDNP3; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3; DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3); DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3); Phosphodiesterase-I Beta
Research Area
Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535).

Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity).

Has also alkaline phosphodiesterase activity (PubMed:11342463).
Biological Process
ATP metabolic process Source: UniProtKB
Basophil activation involved in immune response Source: UniProtKB
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of mast cell activation involved in immune response Source: UniProtKB
Negative regulation of mast cell proliferation Source: UniProtKB
Nucleoside triphosphate catabolic process Source: BHF-UCL
Phosphate-containing compound metabolic process Source: BHF-UCL
Pyrimidine nucleotide metabolic process Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane; Secreted. Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells.
Topology
Cytoplasmic: 1-11
Helical: 12-30
Extracellular: 31-875
PTM
N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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