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Mouse Anti-ENSA (AA 1-121) Recombinant Antibody (CBFYE-0903) (CBMAB-E1372-FY)

This product is mouse antibody that recognizes ENSA. The antibody CBFYE-0903 can be used for immunoassay techniques such as: ELISA, WB.
See all ENSA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0903
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant protein with GST tag. MW of the GST tag alone is 26 kDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-121

Target

Full Name
Endosulfine Alpha
Introduction
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Entrez Gene ID
2029
UniProt ID
O43768
Alternative Names
Endosulfine Alpha; ARPP-19e; Endosulfine-Alpha Variant 1; Endosulfine-Alpha Variant 3; Alpha-Endosulfine
Research Area
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Biological Process
Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Negative regulation of protein dephosphorylation Source: GO_Central
Regulation of insulin secretion Source: MGI
Response to glucose Source: Ensembl
Response to nutrient Source: ProtInc
Cellular Location
Cytoplasm
PTM
Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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