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Mouse Anti-ENTPD1 Recombinant Antibody (7H171) (CBMAB-C0376-CN)

This product is a Mouse antibody that recognizes ENTPD1. The antibody 7H171 can be used for immunoassay techniques such as: FC, IHC, IP, WB.
See all ENTPD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7H171
Antibody Isotype
IgG1
Application
FC, IHC, IP, WB

Basic Information

Immunogen
Human WM-1 (Waldenströms macroglobulinemia) cell line
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50 mM Sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM NaCl
Preservative
0.5 mg/mL Gentamicin sulfate
Concentration
1 mg/mL

Target

Full Name
Ectonucleoside Triphosphate Diphosphohydrolase 1
Introduction
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
953
UniProt ID
P49961
Alternative Names
CD39; SPG64; ATPDase; NTPDase-1
Research Area
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Biological Process
Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Nucleoside diphosphate catabolic process Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Spastic paraplegia 64, autosomal recessive (SPG64):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-478
Helical: 479-499
Cytoplasmic: 500-510
PTM
The N-terminus is blocked.
Palmitoylated in the N-terminal part.

Calame, D. G., Herman, I., Maroofian, R., Marshall, A. E., Donis, K. C., Fatih, J. M., ... & Lupski, J. R. (2022). Biallelic variants in the ectonucleotidase ENTPD1 cause a complex neurodevelopmental disorder with intellectual disability, distinct white matter abnormalities, and spastic paraplegia. Annals of neurology, 92(2), 304-321.

Rocconi, R. P., Stanbery, L., Tang, M., Walter, A., Monk, B. J., Herzog, T. J., ... & Nemunaitis, J. (2022). ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer. Communications medicine, 2(1), 1-9.

Wang, N., Vuerich, M., Kalbasi, A., Graham, J. J., Csizmadia, E., Manickas-Hill, Z. J., ... & Longhi, M. S. (2021). Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. Iscience, 24(10), 103205.

Adhikary, S. R., Cuthbertson, P., Turner, R. J., Sluyter, R., & Watson, D. (2020). A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐versus‐host disease in a humanized mouse model. Immunology and Cell Biology, 98(5), 397-410.

Cui, Q. Q., Hu, Z. L., Hu, Y. L., Chen, X., Wang, J., Mao, L., ... & Wang, F. (2020). Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP. EMBO reports, 21(4), e47857.

Zimmermann, H. (2020). Comments on Cui Q‐Q et al:“Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior…”. EMBO reports, 21(9), e50737.

Yadav, V., Chi, L., Zhao, R., Tourdot, B. E., Yalavarthi, S., Jacobs, B. N., ... & Kanthi, Y. (2019). ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis. The Journal of clinical investigation, 129(7), 2872-2877.

Mamelona, J., Crapoulet, N., & Marrero, A. (2019). A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene. Human genome variation, 6(1), 1-6.

Rothweiler, S., Feldbrügge, L., Jiang, Z. G., Csizmadia, E., Longhi, M. S., Vaid, K., ... & Robson, S. C. (2019). Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic signalling, 15(3), 375-385.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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