ENTPD1

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene.
Full Name
Ectonucleoside Triphosphate Diphosphohydrolase 1
Research Area
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Biological Process
Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Nucleoside diphosphate catabolic process Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Spastic paraplegia 64, autosomal recessive (SPG64):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-478
Helical: 479-499
Cytoplasmic: 500-510
PTM
The N-terminus is blocked.
Palmitoylated in the N-terminal part.
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Anti-ENTPD1 antibodies

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Mouse Anti-ENTPD1 Recombinant Antibody (CBYY-C0377) (CBMAB-C1287-YY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-C0377
Application*: F
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (CBT3680) (V2LY-0625-LY1021)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3680
Application*: IH
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (CBT3685) (V2LY-0625-LY1020)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3685
Application*: WB
Datasheet SDS

Rat Anti-ENTPD1 Recombinant Antibody (CBFYC-2608) (CBMAB-C2682-FY)

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Target: ENTPD1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBFYC-2608
Application*: WB, F
Datasheet SDS

Rabbit Anti-ENTPD1 Recombinant Antibody (5F2) (CBMAB-C7561-LY)

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Target: ENTPD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 5F2
Application*: E
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (22A9) (CBMAB-C4431-LY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 22A9
Application*: WB, IP, IF, F
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (1G8) (CBMAB-C4204-LY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G8
Application*: WB, F, IH, IP
Datasheet SDS

Rabbit Anti-ENTPD1 Recombinant Antibody (004) (CBMAB-C1512-LY)

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Target: ENTPD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 004
Application*: WB, P
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (43) (CBMAB-C1366-LY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 43
Application*: IF, WB, E
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (CBFYE-0906) (CBMAB-E1376-FY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0906
Application*: F
Datasheet SDS

Rat Anti-ENTPD1 Recombinant Antibody (CBFYE-0220) (CBMAB-E0470-FY)

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Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0220
Application*: WB, F, IP
Datasheet SDS

Mouse Anti-ENTPD1 Recombinant Antibody (26) (CBMAB-E1377-FY)

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 26
Application*: F, IF
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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