Human Recombinant ENTPD1 protein, ECD, His Tag (V2LY-0526-LY2831)

Name: Human Recombinant ENTPD1 protein, ECD, His Tag
SKU: V2LY-0526-LY2831
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ENTPD1 protein, ECD, His Tag consist of Amino Acid: 38-478 and predicts a molecular mass of 51.8 kDa.

Molecule Mass

51.8 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 38-478

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Ectonucleoside Triphosphate Diphosphohydrolase 1

Research Area

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Biological Process

Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Nucleoside diphosphate catabolic process Source: GO_Central

Cellular Location

Membrane

Involvement in disease

Spastic paraplegia 64, autosomal recessive (SPG64):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

Topology

Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-478
Helical: 479-499
Cytoplasmic: 500-510

PTM

The N-terminus is blocked.
Palmitoylated in the N-terminal part.

Calame, D. G., Herman, I., Maroofian, R., Marshall, A. E., Donis, K. C., Fatih, J. M., ... & Lupski, J. R. (2022). Biallelic variants in the ectonucleotidase ENTPD1 cause a complex neurodevelopmental disorder with intellectual disability, distinct white matter abnormalities, and spastic paraplegia. Annals of neurology, 92(2), 304-321.

Rocconi, R. P., Stanbery, L., Tang, M., Walter, A., Monk, B. J., Herzog, T. J., ... & Nemunaitis, J. (2022). ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer. Communications medicine, 2(1), 1-9.

Wang, N., Vuerich, M., Kalbasi, A., Graham, J. J., Csizmadia, E., Manickas-Hill, Z. J., ... & Longhi, M. S. (2021). Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. Iscience, 24(10), 103205.

Adhikary, S. R., Cuthbertson, P., Turner, R. J., Sluyter, R., & Watson, D. (2020). A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐versus‐host disease in a humanized mouse model. Immunology and Cell Biology, 98(5), 397-410.

Cui, Q. Q., Hu, Z. L., Hu, Y. L., Chen, X., Wang, J., Mao, L., ... & Wang, F. (2020). Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP. EMBO reports, 21(4), e47857.

Zimmermann, H. (2020). Comments on Cui Q‐Q et al:“Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior…”. EMBO reports, 21(9), e50737.

Yadav, V., Chi, L., Zhao, R., Tourdot, B. E., Yalavarthi, S., Jacobs, B. N., ... & Kanthi, Y. (2019). ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis. The Journal of clinical investigation, 129(7), 2872-2877.

Mamelona, J., Crapoulet, N., & Marrero, A. (2019). A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene. Human genome variation, 6(1), 1-6.

Rothweiler, S., Feldbrügge, L., Jiang, Z. G., Csizmadia, E., Longhi, M. S., Vaid, K., ... & Robson, S. C. (2019). Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic signalling, 15(3), 375-385.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD39 protein, His Tag (CAT#: V2LY-0526-LY1690)

Mouse Recombinant ENTPD1 protein, His Tag (CAT#: V2LY-0526-LY8008)

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Isotype control

For research use only. Not intended for any clinical use.

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