Human ENTPD1 ELISA Kit (2) (V2LY-0626-LY5912)

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Basic Information

Sensitivity
0.048 ng/mL
Detection Range
0.1-35 ng/mL
Sample Type
Serum, Plasma, cell culture supernates, tissue homogenates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
58.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Ectonucleoside Triphosphate Diphosphohydrolase 1
Research Area
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Biological Process
Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Nucleoside diphosphate catabolic process Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Spastic paraplegia 64, autosomal recessive (SPG64):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-478
Helical: 479-499
Cytoplasmic: 500-510
PTM
The N-terminus is blocked.
Palmitoylated in the N-terminal part.

Calame, D. G., Herman, I., Maroofian, R., Marshall, A. E., Donis, K. C., Fatih, J. M., ... & Lupski, J. R. (2022). Biallelic variants in the ectonucleotidase ENTPD1 cause a complex neurodevelopmental disorder with intellectual disability, distinct white matter abnormalities, and spastic paraplegia. Annals of neurology, 92(2), 304-321.

Rocconi, R. P., Stanbery, L., Tang, M., Walter, A., Monk, B. J., Herzog, T. J., ... & Nemunaitis, J. (2022). ENTPD1/CD39 as a predictive marker of treatment response to gemogenovatucel-T as maintenance therapy in newly diagnosed ovarian cancer. Communications medicine, 2(1), 1-9.

Wang, N., Vuerich, M., Kalbasi, A., Graham, J. J., Csizmadia, E., Manickas-Hill, Z. J., ... & Longhi, M. S. (2021). Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. Iscience, 24(10), 103205.

Adhikary, S. R., Cuthbertson, P., Turner, R. J., Sluyter, R., & Watson, D. (2020). A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐versus‐host disease in a humanized mouse model. Immunology and Cell Biology, 98(5), 397-410.

Cui, Q. Q., Hu, Z. L., Hu, Y. L., Chen, X., Wang, J., Mao, L., ... & Wang, F. (2020). Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP. EMBO reports, 21(4), e47857.

Zimmermann, H. (2020). Comments on Cui Q‐Q et al:“Hippocampal CD 39/ENTPD 1 promotes mouse depression‐like behavior…”. EMBO reports, 21(9), e50737.

Yadav, V., Chi, L., Zhao, R., Tourdot, B. E., Yalavarthi, S., Jacobs, B. N., ... & Kanthi, Y. (2019). ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis. The Journal of clinical investigation, 129(7), 2872-2877.

Mamelona, J., Crapoulet, N., & Marrero, A. (2019). A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene. Human genome variation, 6(1), 1-6.

Rothweiler, S., Feldbrügge, L., Jiang, Z. G., Csizmadia, E., Longhi, M. S., Vaid, K., ... & Robson, S. C. (2019). Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic signalling, 15(3), 375-385.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant CD39 protein, His Tag (CAT#: V2LY-0526-LY1690)

Human Recombinant ENTPD1 protein, ECD, His Tag (CAT#: V2LY-0526-LY2831)

Mouse Recombinant ENTPD1 protein, His Tag (CAT#: V2LY-0526-LY8008)

Cattle ENTPD1 ELISA Kit (CAT#: V2LY-0626-LY2513)

Human ENTPD1 ELISA Kit (CAT#: V2LY-0626-LY4527)

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Human ENTPD1 ELISA Kit (CAT#: V2LY-0626-LY4527)

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Mouse Anti-ENTPD1 Recombinant Antibody (CBYY-C0377) (CAT#: CBMAB-C1287-YY)

Isotype control

For research use only. Not intended for any clinical use.

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