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Mouse Anti-ENTPD6 (AA 61-484) Recombinant Antibody (CBFYE-0912) (CBMAB-E1384-FY)

This product is mouse antibody that recognizes ENTPD6. The antibody CBFYE-0912 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all ENTPD6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0912
Antibody Isotype
IgG2b
Application
ELISA, IP, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa61-484 from human CD39L2 lumenal domain expressed in CHO cell cells. Species Sequence Homology: chimpanzee, 99%, mouse, 88%, canine, 87%
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 61-484

Target

Full Name
ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
Introduction
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
UniProt ID
Alternative Names
Ectonucleoside Triphosphate Diphosphohydrolase 6 (Putative); Interleukin 6 Signal Transducer-2; CD39 Antigen-Like 2; NTPDase 6; CD39L2; IL6ST2
Research Area
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856).

The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856).
Biological Process
Nucleoside diphosphate catabolic process Source: GO_Central
Response to calcium ion Source: Ensembl
Response to magnesium ion Source: Ensembl
Cellular Location
Cell membrane; Golgi apparatus membrane; Secreted. Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant.
Topology
Cytoplasmic: 1-39
Helical: 40-60
Lumenal: 61-484
PTM
The secreted form may be produced by intracellular processing.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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