ENTPD6

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
Research Area
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856).

The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856).
Biological Process
Nucleoside diphosphate catabolic process Source: GO_Central
Response to calcium ion Source: Ensembl
Response to magnesium ion Source: Ensembl
Cellular Location
Cell membrane; Golgi apparatus membrane; Secreted. Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant.
Topology
Cytoplasmic: 1-39
Helical: 40-60
Lumenal: 61-484
PTM
The secreted form may be produced by intracellular processing.
N-glycosylated.
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Anti-ENTPD6 antibodies

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Rat Anti-ENTPD6 Recombinant Antibody (510) (CBMAB-C4733-YY)

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Target: ENTPD6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 510
Application*: IF, IH
Datasheet SDS

Mouse Anti-ENTPD6 Recombinant Antibody (2D10) (V2LY-0825-LY330)

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Target: ENTPD6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D10
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-ENTPD6 Recombinant Antibody (CBFYE-0912) (V2LY-0825-LY329)

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Target: ENTPD6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0912
Application*: IF, E, P
Datasheet SDS

Mouse Anti-ENTPD6 Recombinant Antibody (CBFYE-0224) (V2LY-0825-LY328)

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Target: ENTPD6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0224
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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