ENTPD6
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
Research Area
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856).
The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856).
Biological Process
Nucleoside diphosphate catabolic process Source: GO_Central
Response to calcium ion Source: Ensembl
Response to magnesium ion Source: Ensembl
Cellular Location
Cell membrane; Golgi apparatus membrane; Secreted. Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant.
Topology
Cytoplasmic: 1-39
Helical: 40-60
Lumenal: 61-484
PTM
The secreted form may be produced by intracellular processing.
N-glycosylated.
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