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Mouse Anti-EPHA10 (AA 34-283) Recombinant Antibody (CBFYE-0970) (CBMAB-E1454-FY)

This product is mouse antibody that recognizes EPHA10. The antibody CBFYE-0970 can be used for immunoassay techniques such as: IHC.
See all EPHA10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0970
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
E.coli-derived recombinant human EphA10, Glu34-Glu283
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 34-283

Target

Full Name
EPH Receptor A10
Introduction
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005). See MIM 179610 for additional background on Eph receptors and ephrins.
Entrez Gene ID
284656
UniProt ID
Q5JZY3
Alternative Names
EPH Receptor A10; EC 2.7.10.
Research Area
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Biological Process
Axon guidance Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Isoform 1&3: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 34-565
Helical: 566-586
Cytoplasmic: 587-1008

Cha, J. H., Chan, L. C., Wang, Y. N., Chu, Y. Y., Wang, C. H., Lee, H. H., ... & Hung, M. C. (2022). Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. Journal of Biological Chemistry, 298(4).

Zhao, W., Liu, L., Li, X., & Xu, S. (2022). EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma. International Immunopharmacology, 110, 109031.

Chen, Y. L., Yen, Y. C., Jang, C. W., Wang, S. H., Huang, H. T., Chen, C. H., ... & Chen, Y. W. (2021). Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells. Scientific reports, 11(1), 1-17.

Liang, L. Y., Roy, M., Horne, C. R., Sandow, J. J., Surudoi, M., Dagley, L. F., ... & Lucet, I. S. (2021). The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochemical Journal, 478(17), 3351-3371.

Shin, W. S., Park, M. K., Lee, Y. H., Kim, K. W., Lee, H., & Lee, S. T. (2020). The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells. Cancer science, 111(9), 3292-3302.

Chan, L. C., Cha, J. H., Yang, W. H., Xia, W., Lee, H. H., Wang, Y. N., ... & Hung, M. C. (2020). Abstract B02: Ephrin receptor A10 promotes PD-L1 expression for breast cancer immune evasion. Cancer Immunology Research, 8(4_Supplement), B02-B02.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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