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Mouse Anti-EPHA10 Recombinant Antibody (2E8) (CBMAB-EN1312-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E8
Antibody Isotype
IgG
Application
WB, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human Epha10 expressed in E. Coli.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EPH Receptor A10
Introduction
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Entrez Gene ID
284656
UniProt ID
Q5JZY3
Alternative Names
EPH Receptor A10; EC 2.7.10.1;
Research Area
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Biological Process
Axon guidance Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Isoform 1&3: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 34-565
Helical: 566-586
Cytoplasmic: 587-1008
More Infomation

Cha, J. H., Chan, L. C., Wang, Y. N., Chu, Y. Y., Wang, C. H., Lee, H. H., ... & Hung, M. C. (2022). Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. Journal of Biological Chemistry, 298(4).

Zhao, W., Liu, L., Li, X., & Xu, S. (2022). EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma. International Immunopharmacology, 110, 109031.

Chen, Y. L., Yen, Y. C., Jang, C. W., Wang, S. H., Huang, H. T., Chen, C. H., ... & Chen, Y. W. (2021). Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells. Scientific reports, 11(1), 1-17.

Liang, L. Y., Roy, M., Horne, C. R., Sandow, J. J., Surudoi, M., Dagley, L. F., ... & Lucet, I. S. (2021). The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochemical Journal, 478(17), 3351-3371.

Shin, W. S., Park, M. K., Lee, Y. H., Kim, K. W., Lee, H., & Lee, S. T. (2020). The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells. Cancer science, 111(9), 3292-3302.

Chan, L. C., Cha, J. H., Yang, W. H., Xia, W., Lee, H. H., Wang, Y. N., ... & Hung, M. C. (2020). Abstract B02: Ephrin receptor A10 promotes PD-L1 expression for breast cancer immune evasion. Cancer Immunology Research, 8(4_Supplement), B02-B02.

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For research use only. Not intended for any clinical use.

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