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Mouse Anti-Epha10 Recombinant Antibody (CBT2199) (V2LY-0625-LY2621)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2199
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human Epha10 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EPH Receptor A10
Entrez Gene ID
284656
UniProt ID
Q5JZY3
Research Area
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Biological Process
Axon guidance Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Isoform 1&3: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 34-565
Helical: 566-586
Cytoplasmic: 587-1008
More Infomation

Cha, J. H., Chan, L. C., Wang, Y. N., Chu, Y. Y., Wang, C. H., Lee, H. H., ... & Hung, M. C. (2022). Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. Journal of Biological Chemistry, 298(4).

Zhao, W., Liu, L., Li, X., & Xu, S. (2022). EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma. International Immunopharmacology, 110, 109031.

Chen, Y. L., Yen, Y. C., Jang, C. W., Wang, S. H., Huang, H. T., Chen, C. H., ... & Chen, Y. W. (2021). Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells. Scientific reports, 11(1), 1-17.

Liang, L. Y., Roy, M., Horne, C. R., Sandow, J. J., Surudoi, M., Dagley, L. F., ... & Lucet, I. S. (2021). The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochemical Journal, 478(17), 3351-3371.

Shin, W. S., Park, M. K., Lee, Y. H., Kim, K. W., Lee, H., & Lee, S. T. (2020). The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells. Cancer science, 111(9), 3292-3302.

Chan, L. C., Cha, J. H., Yang, W. H., Xia, W., Lee, H. H., Wang, Y. N., ... & Hung, M. C. (2020). Abstract B02: Ephrin receptor A10 promotes PD-L1 expression for breast cancer immune evasion. Cancer Immunology Research, 8(4_Supplement), B02-B02.

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For research use only. Not intended for any clinical use.

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