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Mouse Anti-EPHA8 Recombinant Antibody (CBFYE-0998) (CBMAB-E1496-FY)

This product is mouse antibody that recognizes EPHA8. The antibody CBFYE-0998 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all EPHA8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYE-0998
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Synthetic peptide derived from the ephrin-B sequence
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EPH Receptor A8
Introduction
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
Entrez Gene ID
13842
UniProt ID
O09127
Alternative Names
Eek; Hek3; AW047546; mKIAA1459
Research Area
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
Biological Process
Axon guidance Source: UniProtKB
Cell adhesion Source: UniProtKB-KW
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Ephrin receptor signaling pathway Source: UniProtKB
Neuron projection development Source: UniProtKB
Neuron remodeling Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of cell adhesion mediated by integrin Source: UniProtKB
Substrate-dependent cell migration Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Cell membrane; Early endosome membrane; Cell projection. Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.
Topology
Extracellular: 28-542
Helical: 543-563
Cytoplasmic: 564-1005
PTM
Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).
Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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