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Mouse Anti-EREG Recombinant Antibody (CBFYE-1172) (V2LY-0825-LY686)

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Basic Information

Host Animal
Mouse
Clone
CBFYE-1172
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Amino acids 1-162 representing full length of mouse Epiregulin.
Host Species
Mouse
Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Epiregulin
Entrez Gene ID
13874
UniProt ID
Q61521
Research Area
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975).

Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
Biological Process
Anatomical structure morphogenesis Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Animal organ morphogenesis Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cytokine-mediated signaling pathway Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Female meiotic nuclear division Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Keratinocyte proliferation Source: UniProtKB
Luteinizing hormone signaling pathway Source: UniProtKB
mRNA transcription Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of smooth muscle cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Oocyte maturation Source: UniProtKB
Ovarian cumulus expansion Source: UniProtKB
Ovulation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of mitotic nuclear division Source: UniProtKB
Positive regulation of phosphorylation Source: UniProtKB
Positive regulation of protein kinase activity Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Primary follicle stage Source: UniProtKB
Response to peptide hormone Source: Ensembl
Wound healing Source: UniProtKB
Cellular Location
Epiregulin: Extracellular space
Proepiregulin: Cell membrane
Topology
Extracellular: 60-119
Helical: 120-140
Cytoplasmic: 141-169

Yang, S., Zhang, Y., Guo, C., Liu, R., Elkharti, M., Ge, Z., ... & Sun, M. Z. (2022). The homeostatic malfunction of a novel feedback pathway formed by lncRNA021545, miR-330-3p and epiregulin contributes in hepatocarcinoma progression via mediating epithelial-mesenchymal transition. American Journal of Cancer Research, 12(6), 2492.

Ma, S., Zhang, L., Ren, Y., Dai, W., Chen, T., Luo, L., ... & Cao, B. (2021). Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer. Oncogene, 40(14), 2596-2609.

Chen, K. Y., Tseng, C. H., Feng, P. H., Sun, W. L., Ho, S. C., Lin, C. W., ... & Wu, S. M. (2021). 3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway. Cell Biology and Toxicology, 1-23.

An, L., & Yin, F. (2021). MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis. Tissue and Cell, 73, 101669.

Wu, X., Dong, W., Zhang, T., Ren, H., Wang, J., Shang, L., ... & Xu, Y. (2021). Epiregulin (EREG) and myocardin related transcription factor A (MRTF-A) form a feedforward loop to drive hepatic stellate cell activation. Frontiers in cell and developmental biology, 8, 591246.

Williams, C. J., Seligmann, J. F., Elliott, F., Shires, M., Richman, S. D., Brown, S., ... & Shanmugam, K. (2021). Artificial Intelligence–Assisted Amphiregulin and Epiregulin IHC Predicts Panitumumab Benefit in RAS Wild-Type Metastatic Colorectal CancerAREG and EREG: Predictive Biomarkers for Anti-EGFR Therapy. Clinical Cancer Research, 27(12), 3422-3431.

Wang, Y., Jing, Y., Ding, L., Zhang, X., Song, Y., Chen, S., ... & Hu, Q. (2019). Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Cui, D., Xiao, J., Zhou, Y., Zhou, X., Liu, Y., Peng, Y., ... & Zheng, L. (2019). Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway. Cell proliferation, 52(6), e12680.

Stintzing, S., Ivanova, B., Ricard, I., Jung, A., Kirchner, T., Tannapfel, A., ... & Reinacher-Schick, A. (2018). Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients—Analysis of the Phase III AIO KRK-0207 Trial. Frontiers in Oncology, 8, 474.

Cao, Y., Wang, L., Yang, H., Lin, X., Li, G., Han, N., ... & Fan, Z. (2018). Epiregulin promotes the migration and chemotaxis ability of adipose‐derived mesenchymal stem cells via mitogen‐activated protein kinase signaling pathways. Journal of Cellular Biochemistry, 119(10), 8450-8459.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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