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Mouse Anti-ERF Recombinant Antibody (CBFYE-1183) (CBMAB-E1753-FY)

This product is mouse antibody that recognizes ERF. The antibody CBFYE-1183 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ERF antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-1183
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ets2 repressor factor
Introduction
ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
Human2077
Mouse13875
Rat292721
UniProt ID
HumanP50548
MouseP70459
RatD3ZJW0
Alternative Names
ETS2 Repressor Factor; Ets2 Repressor Factor; PE-2; ETS Domain-Containing Transcription Factor ERF; CHYTS; CRS4; PE2
Research Area
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity).

May be important for regulating trophoblast stem cell differentiation (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Craniosynostosis 4 (CRS4):
A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Chitayat syndrome (CHYTS):
An autosomal dominant syndrome characterized by hyperphalangism, partial syndactyly, bilateral accessory phalanx resulting in shortened index fingers, hallux valgus, brachydactyly, facial anomalies, diffuse bronchomalacia, and respiratory distress at birth and in infancy.
PTM
Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.

Tsiomita, S., Liveri, E. M., Vardaka, P., Vogiatzi, A., Skiadaresis, A., Saridis, G., ... & Thyphronitis, G. (2022). ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment. Journal of Leukocyte Biology.

Cannon-Albright, L. A., Teerlink, C. C., Stevens, J., Huang, F. W., Sipeky, C., Schleutker, J., ... & Trump, D. L. (2021). A Rare Variant in ERF (rs144812092) Predisposes to Prostate and Bladder Cancers in an Extended Pedigree. Cancers, 13(10), 2399.

Bao, X., Zhang, X., Wang, L., Wang, Z., Huang, J., Zhang, Q., ... & Xu, X. (2021). Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia. The American Journal of Human Genetics, 108(4), 709-721.

Yamada, M., Funato, M., Kondo, G., Suzuki, H., Uehara, T., Takenouchi, T., ... & Kosaki, K. (2021). Noonan syndrome‐like phenotype in a patient with heterozygous ERF truncating variant. Congenital Anomalies, 61(6), 226-230.

Vogiatzi, A., Baltsavia, I., Dialynas, E., Theodorou, V., Zhou, Y., Deligianni, E., ... & Mavrothalassitis, G. (2021). Erf affects commitment and differentiation of osteoprogenitor cells in cranial sutures via the retinoic acid pathway. Molecular and Cellular Biology, 41(8), e00149-21.

Yin, X., Zheng, X., Liu, M., Wang, D., Sun, H., Qiu, Y., ... & Shi, B. (2020). Exosomal miR‐663b targets Ets2‐repressor factor to promote proliferation and the epithelial–mesenchymal transition of bladder cancer cells. Cell Biology International, 44(4), 958-965.

Caro‐Contreras, A., Alcántara‐Ortigoza, M. A., Ahumada‐Pérez, J. F., & González‐del Angel, A. (2019). Molecular analysis provides further evidence that Chitayat syndrome is caused by the recurrent p.(Tyr89Cys) pathogenic variant in the ERF gene. American Journal of Medical Genetics Part A, 179(1), 118-122.

Glass, G. E., O'Hara, J., Canham, N., Cilliers, D., Dunaway, D., Fenwick, A. L., ... & Wilson, L. C. (2019). ERF‐related craniosynostosis: The phenotypic and developmental profile of a new craniosynostosis syndrome. American Journal of Medical Genetics Part A, 179(4), 615-627.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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