Sign in or Register   Sign in or Register
  |  

Mouse Anti-ESRP2 Antibody (1D2) (CBMAB-0355-YC)

Provided herein are mouse monoclonal antibodies against Human ESRP2. The antibody clone 1D2 can be used for immunoassay techniques, such as IP and MA.
See all ESRP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D2
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ESRP2
Introduction
ESRP2 (epithelial splicing regulatory protein 2) is an epithelial cell-type-specific splicing regulator.
Entrez Gene ID
80004
UniProt ID
Q9H6T0
Alternative Names
FLJ21918; RBM35B
Research Area
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Biological Process
Alternative mRNA splicing, via spliceosome Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Regulation of RNA splicing Source: UniProtKB
Cellular Location
Nucleus

Shen, D., Ding, L., Lu, Z., Wang, R., Yu, C., Wang, H., ... & Li, G. (2022). METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination. Molecular Therapy-Nucleic Acids, 27, 547-561.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2022). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. Molecular oncology, 16(3), 630-647.

Hyun, J., Al Abo, M., Dutta, R. K., Oh, S. H., Xiang, K., Zhou, X., ... & Diehl, A. M. (2021). Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. Journal of Hepatology, 75(3), 623-633.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2021). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. bioRxiv, 2020-11.

Becker, T., Pich, A., Tamm, S., Hedtfeld, S., Ibrahim, M., Altmüller, J., ... & Stanke, F. (2020). Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. Scientific reports, 10(1), 1-19.

Yue, P. J., Sun, Y. Y., Li, Y. H., Xu, Z. M., & Fu, W. N. (2020). MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway. Cellular Signalling, 74, 109709.

Freytag, M., Kluth, M., Bady, E., Hube-Magg, C., Makrypidi-Fraune, G., Heinzer, H., ... & Möller, K. (2020). Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer. BMC cancer, 20(1), 1-12.

Munkley, J., Li, L., Krishnan, S. G., Hysenaj, G., Scott, E., Dalgliesh, C., ... & Elliott, D. J. (2019). Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife, 8.

Lu, G., Duan, J., & Zhou, D. (2018). Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas. Pathology-Research and Practice, 214(12), 2054-2061.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ESRP2 Antibody (1D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare