Mouse Anti-ESRP2 Recombinant Antibody (23) (CBMAB-E1896-FY)

Name: Mouse Anti-ESRP2 Recombinant Antibody (23)
SKU: CBMAB-E1896-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

ELISA, WB

Immunogen

Full length recombinant mouse Esrp-2 fusion protein.

Host Species

Mouse

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:10,0000
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ESRP2

Introduction

ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009).

Entrez Gene ID

77411

UniProt ID

Q8K0G8

Alternative Names

Rbm35b; 9530027K23Rik

Research Area

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Biological Process

Alternative mRNA splicing, via spliceosome Source: Ensembl
Branching involved in salivary gland morphogenesis Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Regulation of RNA splicing Source: UniProtKB

Cellular Location

Nucleus

Shen, D., Ding, L., Lu, Z., Wang, R., Yu, C., Wang, H., ... & Li, G. (2022). METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination. Molecular Therapy-Nucleic Acids, 27, 547-561.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2022). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. Molecular oncology, 16(3), 630-647.

Hyun, J., Al Abo, M., Dutta, R. K., Oh, S. H., Xiang, K., Zhou, X., ... & Diehl, A. M. (2021). Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. Journal of Hepatology, 75(3), 623-633.

Legge, D., Li, L., Moriarty, W., Lee, D., Szemes, M., Zahed, A., ... & Brown, K. W. (2021). The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor. bioRxiv, 2020-11.

Becker, T., Pich, A., Tamm, S., Hedtfeld, S., Ibrahim, M., Altmüller, J., ... & Stanke, F. (2020). Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B. Scientific reports, 10(1), 1-19.

Yue, P. J., Sun, Y. Y., Li, Y. H., Xu, Z. M., & Fu, W. N. (2020). MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway. Cellular Signalling, 74, 109709.

Freytag, M., Kluth, M., Bady, E., Hube-Magg, C., Makrypidi-Fraune, G., Heinzer, H., ... & Möller, K. (2020). Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer. BMC cancer, 20(1), 1-12.

Munkley, J., Li, L., Krishnan, S. G., Hysenaj, G., Scott, E., Dalgliesh, C., ... & Elliott, D. J. (2019). Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife, 8.

Lu, G., Duan, J., & Zhou, D. (2018). Long-noncoding RNA IFNG-AS1 exerts oncogenic properties by interacting with epithelial splicing regulatory protein 2 (ESRP2) in pituitary adenomas. Pathology-Research and Practice, 214(12), 2054-2061.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ESRP2 Monoclonal Antibody (CBFYE-1298) (CAT#: CBMAB-E1895-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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