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Mouse Anti-EYS (AA 309-408) Recombinant Antibody (CBFYE-0270) (CBMAB-E0549-FY)

This product is mouse antibody that recognizes EYS. The antibody CBFYE-0270 can be used for immunoassay techniques such as: ELISA, WB.
See all EYS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0270
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
EYS partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: HVVVIQNQTL IKAYINNSLI LSEDIDPHKN FVALNYDGIC YLGGFEYGRK VNIVTQEIFK TNFVGKIKDV VFFQEPKNIE LIKLEGYNVY DGDEQNEVT
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 309-408

Target

Full Name
eyes shut homolog (Drosophila)
Introduction
The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
346007
UniProt ID
Q5T1H1
Alternative Names
Eyes Shut Homolog (Drosophila); Epidermal Growth Factor-Like Protein 10; Epidermal Growth Factor-Like Protein 11; EGF-Like-Domain, Multiple 11; EGF-Like-Domain, Multiple 10; Protein Spacemaker Homolog; C6orf178; C6orf179; C6orf180; EGFL10; EGFL11; SPAM; Retinitis Pigmentosa 25 (Autosomal Recessive); Chromosome 6 Open Reading Frame 180
Research Area
Required to maintain the integrity of photoreceptor cells (PubMed:18836446).

Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity).
Biological Process
Detection of light stimulus involved in visual perception Source: UniProtKB
Skeletal muscle tissue regeneration Source: UniProtKB
Cellular Location
Interphotoreceptor matrix; Cilium axoneme; Centrosome; Photoreceptor outer segment; Cilium. Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822). Highly expressed in cone photoreceptor outer segments (PubMed:27737822). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (PubMed:27846257). May also be secreted into the interphotoreceptor extracellular matrix (PubMed:27737822).
Involvement in disease
Retinitis pigmentosa 25 (RP25):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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