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Mouse Anti-F10 Recombinant Antibody (CBXF-1404) (CBMAB-F1653-CQ)

This product is a mouse antibody that recognizes F10. The antibody CBXF-1404 can be used for immunoassay techniques such as: WB.
See all F10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1404
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
A region within amino acids 24 and 488 of human Coagulation factor X
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coagulation Factor X
Introduction
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Entrez Gene ID
2159
UniProt ID
P00742
Alternative Names
Coagulation Factor X; Stuart-Prower Factor; EC 3.4.21.6; Prothrombinase; Stuart Factor; Factor Xa; EC 3.4.21; FXA; FX;
Research Area
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Biological Process
Blood coagulation Source: GO_Central
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Factor X deficiency (FA10D):
A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
PTM
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Ichinose, A., Osaki, T., & Souri, M. (2022). Autoimmune coagulation factor X deficiency as a rare acquired hemorrhagic disorder: a literature review. Thrombosis and Haemostasis, 122(03), 320-328.

Camire, R. M. (2021). Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics. Journal of Thrombosis and Thrombolysis, 52(2), 383-390.

Feng, Y., Ma, J., Tang, L. V., Lin, W., Tao, Y., Cheng, Z., & Hu, Y. (2021). Characterization of a Missense Mutation in the Catalytic Domain and a Splicing Mutation of Coagulation Factor X Compound Heterozygous in a Chinese Pedigree. Genes, 12(10), 1521.

Gill, D., & Burgess, S. (2020). Use of a genetic variant related to circulating FXa (Activated Factor X) levels to proxy the effect of FXa inhibition on cardiovascular outcomes. Circulation: Genomic and Precision Medicine, 13(5), 551-553.

Paraboschi, E. M., Khera, A. V., Merlini, P. A., Gigante, L., Peyvandi, F., Chaffin, M., ... & Duga, S. (2020). Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease. haematologica, 105(7), e365.

Mitchell, M., Gattens, M., Kavakli, K., Liesner, R., Payne, J., Norton, M., & Austin, S. (2019). Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency. Blood Coagulation & Fibrinolysis, 30(1), 34-41.

Choby, J. E., Monteith, A. J., Himmel, L. E., Margaritis, P., Shirey-Rice, J. K., Pruijssers, A., ... & Skaar, E. P. (2019). A phenome-wide association study uncovers a pathological role of coagulation factor X during Acinetobacter baumannii infection. Infection and immunity, 87(5), e00031-19.

Arita, K., Niimi, H., Yamagishi, N., Ueno, T., Kitajima, I., & Sugiyama, T. (2018). Factor X heterozygous mutation in a patient with potential risk of bleeding: a case report. Medicine, 97(23).

Borhany, M., Buthiau, D., Rousseau, F., Guillot, O., Naveena, F., Abid, M., ... & Giansily-Blaizot, M. (2018). Genotyping of five Pakistani patients with severe inherited factor X deficiency: identification of two novel mutations. Blood Coagulation & Fibrinolysis, 29(7), 622-625.

Chen, T., Li, F., Shu, K., Liu, J., Shen, C., Zhang, Z., ... & Jiang, M. (2018). Genotypic and phenotypic analysis of a case with inherited coagulation factor X deficiency. Zhonghua yi xue yi Chuan xue za zhi= Zhonghua Yixue Yichuanxue Zazhi= Chinese Journal of Medical Genetics, 35(4), 544-547.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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