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F10

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Full Name

Coagulation Factor X

Research Area

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Biological Process

Blood coagulation Source: GO_Central
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL

Cellular Location

Secreted

Involvement in disease

Factor X deficiency (FA10D):
A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.

PTM

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Anti-F10 antibodies

Rat Anti-F10 Recombinant Antibody (CBXF-0130) (CBMAB-F1813-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXF-0130

Application*: E, WB, BL

Rat Anti-F10 Recombinant Antibody (CBXF-2204) (CBMAB-F1884-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXF-2204

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-0124) (CBMAB-F2145-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0124

Application*: E

Mouse Anti-F10 Recombinant Antibody (CBXF-1910) (CBMAB-F2728-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1910

Application*: WB

Rat Anti-F10 Recombinant Antibody (CBXF-1706) (CBMAB-F3241-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXF-1706

Application*: WB

Mouse Anti-F10 Recombinant Antibody (CBWJC-3636) (CBMAB-C4880WJ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3636

Application*: E

Mouse Anti-F10 Recombinant Antibody (CBWJC-2133) (CBMAB-C2844WJ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-2133

Application*: E, WB

Rat Anti-F10 Recombinant Antibody (CBXF-1516) (CBMAB-F4012-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXF-1516

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBFYC-2623) (CBMAB-C2697-FY)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2623

Application*: P

Mouse Anti-F10 Recombinant Antibody (CBFYC-0488) (CBMAB-C0537-FY)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0488

Application*: WB

Mouse Anti-F10 Monoclonal Antibody (CBFYR0361) (CBMAB-R0361-FY)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYR0361

Application*: WB

Mouse Anti-F10 Recombinant Antibody (CaFX-50) (CBMAB-F0024-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CaFX-50

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-0133) (CBMAB-F0025-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0133

Application*: R, WB

Rat Anti-F10 Recombinant Antibody (CBXF-0125) (CBMAB-F0026-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXF-0125

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-0127) (CBMAB-F0760-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Sheep, Rabbit, Cattle, Dog, Human, Pig

Clone: CBXF-0127

Application*: WB, E, R

Rabbit Anti-F10 Recombinant Antibody (CBXF-1139) (CBMAB-F0761-CQ)

SDS

Target: F10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1139

Application*: WB, P

Mouse Anti-F10 Recombinant Antibody (CBXF-2206) (CBMAB-F1573-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2206

Application*: I

Mouse Anti-F10 Recombinant Antibody (CBXF-2207) (CBMAB-F1574-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Dog, Human, Sheep, Pig, Rabbit

Clone: CBXF-2207

Application*: I, R, WB

Mouse Anti-F10 Recombinant Antibody (3C8-B9) (CBMAB-F1651-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3C8-B9

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-1404) (CBMAB-F1653-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1404

Application*: WB

Mouse Anti-F10 Recombinant Antibody (CBXF-0128) (CBMAB-F1810-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0128

Application*: E, WB

Rat Anti-F10 Recombinant Antibody (CBXF-0129) (CBMAB-F1812-CQ)

SDS

Target: F10

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXF-0129

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-0132) (CBMAB-F1814-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXF-0132

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-2132) (CBMAB-F2633-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-2132

Application*: WB

Mouse Anti-F10 Recombinant Antibody (CBXF-2752) (CBMAB-F3469-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-2752

Application*: E

Mouse Anti-F10 Recombinant Antibody (CBXF-2753) (CBMAB-F3470-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Dog, Human, Pig, Rabbit, Sheep

Clone: CBXF-2753

Application*: E, R, WB

Mouse Anti-F10 Recombinant Antibody (CBXF-2754) (CBMAB-F3471-CQ)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2754

Application*: E, WB

Mouse Anti-F10 Recombinant Antibody (14L268) (CBMAB-C3146-LY)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 14L268

Application*: WB

Mouse Anti-F10 Recombinant Antibody (156106) (CBMAB-C3218-LY)

SDS

Target: F10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 156106

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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