F10

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Full Name
Coagulation Factor X
Research Area
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Biological Process
Blood coagulation Source: GO_Central
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Factor X deficiency (FA10D):
A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
PTM
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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Anti-F10 antibodies

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Mouse Anti-F10 Recombinant Antibody (CBXF-1910) (V2LY-0825-LY1031)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1910
Application*: E
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-2132) (V2LY-0825-LY1030)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2132
Application*: WB, IP
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-0124) (V2LY-0825-LY1029)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0124
Application*: E
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-0132) (V2LY-0825-LY1028)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0132
Application*: P
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-0128) (V2LY-0825-LY1027)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0128
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-1404) (V2LY-0825-LY1026)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1404
Application*: E, WB
Datasheet SDS

Rat Anti-F10 Recombinant Antibody (F1651) (V2LY-0825-LY1025)

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Target: F10
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: F1651
Application*: WB
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-2207) (V2LY-0825-LY1024)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2207
Application*: IH
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-2206) (V2LY-0825-LY1023)

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Target: F10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2206
Application*: E, WB
Datasheet SDS

Rabbit Anti-F10 Recombinant Antibody (CBXF-1139) (V2LY-0825-LY1022)

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Target: F10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1139
Application*: E
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-0127) (V2LY-0825-LY1021)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0127
Application*: E, WB
Datasheet SDS

Mouse Anti-F10 Recombinant Antibody (CBXF-0133) (V2LY-0825-LY1020)

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Target: F10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0133
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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