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Mouse Anti-F10 Recombinant Antibody (CBXF-0132) (V2LY-0825-LY1028)

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Basic Information

Host Animal
Mouse
Clone
CBXF-0132
Application
IHC-P
Immunogen
Recombinant Human Coagulation Factor X / F10 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Coagulation Factor X
Entrez Gene ID
2159
UniProt ID
P00742
Research Area
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Biological Process
Blood coagulation Source: GO_Central
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Factor X deficiency (FA10D):
A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
PTM
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Ichinose, A., Osaki, T., & Souri, M. (2022). Autoimmune coagulation factor X deficiency as a rare acquired hemorrhagic disorder: a literature review. Thrombosis and Haemostasis, 122(03), 320-328.

Camire, R. M. (2021). Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics. Journal of Thrombosis and Thrombolysis, 52(2), 383-390.

Feng, Y., Ma, J., Tang, L. V., Lin, W., Tao, Y., Cheng, Z., & Hu, Y. (2021). Characterization of a Missense Mutation in the Catalytic Domain and a Splicing Mutation of Coagulation Factor X Compound Heterozygous in a Chinese Pedigree. Genes, 12(10), 1521.

Gill, D., & Burgess, S. (2020). Use of a genetic variant related to circulating FXa (Activated Factor X) levels to proxy the effect of FXa inhibition on cardiovascular outcomes. Circulation: Genomic and Precision Medicine, 13(5), 551-553.

Paraboschi, E. M., Khera, A. V., Merlini, P. A., Gigante, L., Peyvandi, F., Chaffin, M., ... & Duga, S. (2020). Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease. haematologica, 105(7), e365.

Mitchell, M., Gattens, M., Kavakli, K., Liesner, R., Payne, J., Norton, M., & Austin, S. (2019). Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency. Blood Coagulation & Fibrinolysis, 30(1), 34-41.

Choby, J. E., Monteith, A. J., Himmel, L. E., Margaritis, P., Shirey-Rice, J. K., Pruijssers, A., ... & Skaar, E. P. (2019). A phenome-wide association study uncovers a pathological role of coagulation factor X during Acinetobacter baumannii infection. Infection and immunity, 87(5), e00031-19.

Arita, K., Niimi, H., Yamagishi, N., Ueno, T., Kitajima, I., & Sugiyama, T. (2018). Factor X heterozygous mutation in a patient with potential risk of bleeding: a case report. Medicine, 97(23).

Borhany, M., Buthiau, D., Rousseau, F., Guillot, O., Naveena, F., Abid, M., ... & Giansily-Blaizot, M. (2018). Genotyping of five Pakistani patients with severe inherited factor X deficiency: identification of two novel mutations. Blood Coagulation & Fibrinolysis, 29(7), 622-625.

Chen, T., Li, F., Shu, K., Liu, J., Shen, C., Zhang, Z., ... & Jiang, M. (2018). Genotypic and phenotypic analysis of a case with inherited coagulation factor X deficiency. Zhonghua yi xue yi Chuan xue za zhi= Zhonghua Yixue Yichuanxue Zazhi= Chinese Journal of Medical Genetics, 35(4), 544-547.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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