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Mouse Anti-FABP1 Recombinant Antibody (CBXF-2788) (CBMAB-F3501-CQ)

This product is a mouse antibody that recognizes FABP1. The antibody CBXF-2788 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all FABP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2788
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fatty Acid Binding Protein 1
Introduction
This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
Entrez Gene ID
2168
UniProt ID
P07148
Alternative Names
Fatty Acid Binding Protein 1; Liver-Type Fatty Acid-Binding Protein; Fatty Acid Binding Protein 1, Liver; L-FABP; FABPL; Fatty Acid-Binding Protein, Liver; Fatty Acid-Binding Protein 1;
Research Area
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850).

Binds cholesterol (PubMed:25732850).

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Biological Process
Cellular response to hydrogen peroxide Source: UniProtKB
Cellular response to hypoxia Source: UniProtKB
Intestinal absorption Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of fatty acid beta-oxidation Source: Ensembl
Positive regulation of hydrolase activity Source: Ensembl
Cellular Location
Cytoplasm

Khalifa, O., Al-Akl, N. S., Errafii, K., & Arredouani, A. (2022). Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway. Scientific Reports, 12(1), 1-13.

Yang, F., Gan, L., Pan, J., Chen, Y., Zhang, H., & Huang, L. (2022). Integrated Single-Cell RNA-Sequencing Analysis of Gastric Cancer Identifies FABP1 as a Novel Prognostic Biomarker. Journal of Oncology, 2022.

Cavazza, A., & McPhail, M. J. (2021). Absolutely FABulous? FABP-1 in Non-acetaminophen-related Acute Liver Failure. Digestive Diseases and Sciences, 66(1), 10-11.

Kawakami, R., Matsui, M., Konno, A., Kaneko, R., Shrestha, S., Shrestha, S., ... & Iso, T. (2021). Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury. The Journal of Pathology, 255(4), 362-373.

Valizadeh, M., Aghasizadeh, M., Nemati, M., Hashemi, M., Aghaee-Bakhtiari, S. H., Zare-Feyzabadi, R., ... & Ghayour-Mobarhan, M. (2021). The association between a Fatty Acid Binding Protein 1 (FABP1) gene polymorphism and serum lipid abnormalities in the MASHAD cohort study. Prostaglandins, Leukotrienes and Essential Fatty Acids, 172, 102324.

Valizadeh, M., Aghasizadeh, M., Saberi-Karimian, M., Safari, M., Rohban, M., Bana, H. S., ... & Ghayour-Mobarhan, M. (2021). Association of macro-and micro-nutrients dietary intakes with rs2241883 genetic variants of FABP 1 gene in MASHAD study population. Clinical nutrition ESPEN, 45, 262-266.

Liu, S., Ni, C., Li, Y., Yin, H., Xing, C., Yuan, Y., & Gong, Y. (2021). The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer. Frontiers in molecular biosciences, 8.

Tsai, I. T., Wu, C. C., Hung, W. C., Lee, T. L., Hsuan, C. F., Wei, C. T., ... & Wang, C. P. (2020). FABP1 and FABP2 as markers of diabetic nephropathy. International journal of medical sciences, 17(15), 2338.

Lu, Y. C., Chang, C. C., Wang, C. P., Hung, W. C., Tsai, I. T., Tang, W. H., ... & Hsu, C. C. (2020). Circulating fatty acid-binding protein 1 (FABP1) and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. International Journal of Medical Sciences, 17(2), 182.

Pi, H., Liu, M., Xi, Y., Chen, M., Tian, L., Xie, J., ... & Gao, F. (2019). Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery. The FASEB Journal, 33(11), 11870-11883.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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