Mouse Anti-FANCF Recombinant Antibody (CBXF-2842) (CBMAB-F3552-CQ)

Name: Mouse Anti-FANCF Recombinant Antibody (CBXF-2842)
SKU: CBMAB-F3552-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2842

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 41-350 of human FANCF.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fanconi anemia, complementation group F

Introduction

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F.

Entrez Gene ID

2188

UniProt ID

Q9NPI8

Alternative Names

Fanconi Anemia Complementation Group F; Fanconi Anemia Group F Protein; Protein FACF; FAF;

Research Area

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).

Biological Process

Cellular response to DNA damage stimulus Source: GO_Central
Interstrand cross-link repair Source: InterPro

Cellular Location

Nucleus

Involvement in disease

Fanconi anemia complementation group F (FANCF):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Suh, E., Shin, S., Ju, H. Y., Yoo, K. H., Kim, H. Y., Cho, D., ... & Kim, H. J. (2023). The First Case of Acute Myeloid Leukemia With Underlying Fanconi Anemia due to FANCF Variants in Korea. Annals of laboratory medicine, 43(2), 204-207.

He, M., Sun, H. G., Hao, J. Y., Li, Y. L., Yu, J. K., Yan, Y. Y., ... & Wei, M. J. (2022). [Corrigendum) RNA interference‑mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin‑induced apoptosis dependent on JNK activation. Oncology Reports, 47(6), 1-2.

Singh, D. K., Salinas-Gamboa, R., Singh, A. K., Walkemeir, B., Van Leene, J., De Jaeger, G., ... & Mercier, R. (2022). The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination. bioRxiv.

Lin, S., Yu, L., Song, X., Bi, J., Jiang, L., Wang, Y., ... & Wei, M. (2022). Correction: Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response. Cell Death & Disease, 13(1), 1-2.

Yu, H., Pan, R., Gao, T., Wu, D., Ying, J., & Duan, S. (2020). FANCF hypomethylation is associated with colorectal cancer in Han Chinese. The Turkish Journal of Gastroenterology, 31(8), 558.

Lin, S., Yu, L., Song, X., Bi, J., Jiang, L., Wang, Y., ... & Wei, M. (2019). Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response. Cell death & disease, 10(9), 1-15.

Moes-Sosnowska, J., Rzepecka, I. K., Chodzynska, J., Dansonka-Mieszkowska, A., Szafron, L. M., Balabas, A., ... & Kupryjanczyk, J. (2019). Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas. Cancer biology & therapy, 20(6), 843-854.

Zareifar, S., Dastsooz, H., Shahriari, M., Faghihi, M. A., Shekarkhar, G., Bordbar, M., ... & Shakibazad, N. (2019). A novel frame-shift deletion in FANCF gene causing autosomal recessive Fanconi anemia: a case report. BMC medical genetics, 20(1), 1-7.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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