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Mouse Anti-FANCF Recombinant Antibody (3C4) (CBMAB-A2829-LY)

The product is antibody recognizes FANCF. The antibody 3C4 immunoassay techniques such as: IF, ELISA.
See all FANCF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C4
Antibody Isotype
IgG1, κ
Application
IF, ELISA

Basic Information

Immunogen
FANCF (NP_073562.1, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fanconi anemia, complementation group F
Introduction
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq]
Entrez Gene ID
2188
UniProt ID
Q9NPI8
Alternative Names
FAF; MGC126856
Research Area
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
Biological Process
Cellular response to DNA damage stimulus Source: GO_Central
Interstrand cross-link repair Source: InterPro
Cellular Location
Nucleus
Involvement in disease
Fanconi anemia complementation group F (FANCF):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Suh, E., Shin, S., Ju, H. Y., Yoo, K. H., Kim, H. Y., Cho, D., ... & Kim, H. J. (2023). The First Case of Acute Myeloid Leukemia With Underlying Fanconi Anemia due to FANCF Variants in Korea. Annals of laboratory medicine, 43(2), 204-207.

He, M., Sun, H. G., Hao, J. Y., Li, Y. L., Yu, J. K., Yan, Y. Y., ... & Wei, M. J. (2022). [Corrigendum) RNA interference‑mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin‑induced apoptosis dependent on JNK activation. Oncology Reports, 47(6), 1-2.

Singh, D. K., Salinas-Gamboa, R., Singh, A. K., Walkemeir, B., Van Leene, J., De Jaeger, G., ... & Mercier, R. (2022). The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination. bioRxiv.

Lin, S., Yu, L., Song, X., Bi, J., Jiang, L., Wang, Y., ... & Wei, M. (2022). Correction: Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response. Cell Death & Disease, 13(1), 1-2.

Yu, H., Pan, R., Gao, T., Wu, D., Ying, J., & Duan, S. (2020). FANCF hypomethylation is associated with colorectal cancer in Han Chinese. The Turkish Journal of Gastroenterology, 31(8), 558.

Lin, S., Yu, L., Song, X., Bi, J., Jiang, L., Wang, Y., ... & Wei, M. (2019). Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response. Cell death & disease, 10(9), 1-15.

Moes-Sosnowska, J., Rzepecka, I. K., Chodzynska, J., Dansonka-Mieszkowska, A., Szafron, L. M., Balabas, A., ... & Kupryjanczyk, J. (2019). Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas. Cancer biology & therapy, 20(6), 843-854.

Zareifar, S., Dastsooz, H., Shahriari, M., Faghihi, M. A., Shekarkhar, G., Bordbar, M., ... & Shakibazad, N. (2019). A novel frame-shift deletion in FANCF gene causing autosomal recessive Fanconi anemia: a case report. BMC medical genetics, 20(1), 1-7.

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For research use only. Not intended for any clinical use.

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