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Mouse Anti-FBXL19 Recombinant Antibody (3C5) (CBMAB-A2872-LY)

The product is antibody recognizes FBXL19. The antibody 3C5 immunoassay techniques such as: WB, ELISA.
See all FBXL19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FBXL19 (NP_061958.1, 365 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 19
Introduction
Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM
Entrez Gene ID
54620
UniProt ID
Q6PCT2
Alternative Names
DKFZp434K0410; Fbl19; JHDM1C; MGC50505
Research Area
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).

Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034).
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
Protein demethylation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytosol; SCF ubiquitin ligase complex

Wang, L., Zhang, X., Liu, Y., & Xu, S. (2020). Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma. Journal of cellular physiology, 235(4), 3612-3625.

Jin, L., Huang, S., Guan, C., & Chang, S. (2020). ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis. Cancer cell international, 20(1), 1-16.

Liu, X., Wu, P., Su, R., Xue, Y., Yang, C., Wang, D., ... & Liu, Y. (2020). IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. RNA biology, 17(12), 1777-1788.

Jiang, Q., Cheng, L., Ma, D., & Zhao, Y. (2019). FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer. Bioscience reports, 39(1).

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., ... & Mendell, J. T. (2019). miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19. Genes & development, 33(19-20), 1367-1380.

Dong, G., Pan, T., Zhou, D., Li, C., Liu, J., & Zhang, J. (2019). FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer. Acta Biochimica et Biophysica Sinica, 51(11), 1106-1113.

Ding, Z., Ye, P., Yang, X., & Cai, H. (2019). LncRNA FBXL19-AS1 promotes breast cancer cells proliferation and invasion via acting as a molecular sponge to miR-718. Bioscience reports, 39(4).

Zhang, Y., Xiao, X., Zhou, W., Hu, J., & Zhou, D. (2019). LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66. In Vitro Cellular & Developmental Biology-Animal, 55(6), 426-435.

Pan, R., He, Z., Ruan, W., Li, S., Chen, H., Chen, Z., ... & Nie, Y. (2018). lncRNA FBXL19-AS1 regulates osteosarcoma cell proliferation, migration and invasion by sponging miR-346. OncoTargets and therapy, 11, 8409.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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