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Rabbit Anti-FBXL19 Recombinant Antibody (CBXF-1094) (CBMAB-F0819-CQ)

This product is a rabbit antibody that recognizes FBXL19. The antibody CBXF-1094 can be used for immunoassay techniques such as: WB, IF.
See all FBXL19 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1094
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 19
Introduction
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human54620
Mouse233902
Rat308999
UniProt ID
HumanQ6PCT2
MouseQ6PB97
RatD4A2L9
Alternative Names
F-Box And Leucine Rich Repeat Protein 19; Jumonji C Domain-Containing Histone Demethylase 1C; Fbl19; F-Box And Leucine-Rich Repeat Protein 19; F-Box/LRR-Repeat Protein 19; CXXC11; JHDM1C;
Research Area
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).

Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034).
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
Protein demethylation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytosol; SCF ubiquitin ligase complex

Wang, L., Zhang, X., Liu, Y., & Xu, S. (2020). Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma. Journal of cellular physiology, 235(4), 3612-3625.

Jin, L., Huang, S., Guan, C., & Chang, S. (2020). ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis. Cancer cell international, 20(1), 1-16.

Liu, X., Wu, P., Su, R., Xue, Y., Yang, C., Wang, D., ... & Liu, Y. (2020). IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. RNA biology, 17(12), 1777-1788.

Jiang, Q., Cheng, L., Ma, D., & Zhao, Y. (2019). FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer. Bioscience reports, 39(1).

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., ... & Mendell, J. T. (2019). miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19. Genes & development, 33(19-20), 1367-1380.

Dong, G., Pan, T., Zhou, D., Li, C., Liu, J., & Zhang, J. (2019). FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer. Acta Biochimica et Biophysica Sinica, 51(11), 1106-1113.

Ding, Z., Ye, P., Yang, X., & Cai, H. (2019). LncRNA FBXL19-AS1 promotes breast cancer cells proliferation and invasion via acting as a molecular sponge to miR-718. Bioscience reports, 39(4).

Zhang, Y., Xiao, X., Zhou, W., Hu, J., & Zhou, D. (2019). LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66. In Vitro Cellular & Developmental Biology-Animal, 55(6), 426-435.

Pan, R., He, Z., Ruan, W., Li, S., Chen, H., Chen, Z., ... & Nie, Y. (2018). lncRNA FBXL19-AS1 regulates osteosarcoma cell proliferation, migration and invasion by sponging miR-346. OncoTargets and therapy, 11, 8409.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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