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Mouse Anti-FBXL20 Recombinant Antibody (2G1) (CBMAB-A2873-LY)

The product is antibody recognizes FBXL20. The antibody 2G1 immunoassay techniques such as: WB, ELISA.
See all FBXL20 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FBXL20 (AAH07557, 1 a.a. ~ 436 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 20
Introduction
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM
Entrez Gene ID
84961
UniProt ID
Q96IG2
Alternative Names
Fbl2; Fbl20; MGC15482; SCR; SCRAPPER
Research Area
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
Biological Process
Behavioral fear response Source: Ensembl
Regulation of protein catabolic process at presynapse, modulating synaptic transmission Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Cytoplasm

Liu, J., Zhan, W., Chen, G., Yan, S., Chen, W., & Li, R. (2022). SP1-induced PROX1-AS1 contributes to tumor progression by regulating miR-326/FBXL20 axis in colorectal cancer. Cellular Signalling, 110503.

Sun, R., & Lim, S. O. (2022). FBXL20‐mediated ubiquitination triggers the proteasomal degradation of 4‐1BB. The FEBS Journal.

Liu, J., Huang, S., Liao, X., Chen, Z., Li, L., Yu, L., ... & Li, R. (2021). LncRNA EWSAT1 promotes colorectal cancer progression through sponging miR-326 to modulate FBXL20 expression. OncoTargets and therapy, 14, 367.

Wu, D., Liu, C., & Hong, L. (2021). F-Box and Leucine-Rich Repeat Protein 20 (FBXL20), Negatively Regulated by microRNA (miR)-195-5p, Accelerates the Malignant Progression of Ovarian Cancer. Molecular Biotechnology, 63(12), 1235-1243.

Manne, R. K., Agrawal, Y., Malonia, S. K., Banday, S., Edachery, S., Patel, A., ... & Santra, M. K. (2021). FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. Journal of Biological Chemistry, 297(4).

Madduri, L. S., Brandquist, N. D., Palanivel, C., Talmon, G. A., Baine, M. J., Zhou, S., ... & Yan, Y. (2021). p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase. Neoplasia, 23(12), 1192-1203.

Zheng, S., & Fu, Y. (2020). Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis. Translational oncology, 13(12), 100863.

Yang, Q., Qiao, X., Li, D., Chen, B., Zhang, L., Yuan, C., & Lin, H. (2019). Expression and association of IL-21, FBXL20 and tumour suppressor gene PTEN in laryngeal cancer. Saudi Journal of Biological Sciences, 26(8), 2048-2051.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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