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Mouse Anti-FBXL3 Recombinant Antibody (1A3) (CBMAB-A2875-LY)

The product is antibody recognizes FBXL3. The antibody 1A3 immunoassay techniques such as: WB, ELISA.
See all FBXL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FBXL3 (NP_036290, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 3
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq]
Entrez Gene ID
26224
UniProt ID
Q9UKT7
Alternative Names
FBL3; FBL3A; FBXL3A
Research Area
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346).

The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346).

Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).
Biological Process
Entrainment of circadian clock by photoperiod Source: UniProtKB
G2/M transition of mitotic cell cycle Source: GO_Central
Protein destabilization Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of circadian rhythm Source: UniProtKB
Rhythmic process Source: UniProtKB-KW
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Predominantly nuclear.
Involvement in disease
Intellectual developmental disorder with short stature, facial anomalies, and speech defects (IDDSFAS):
An autosomal recessive disorder characterized by global developmental delay, mildly to severely impaired intellectual development, delayed or slurred speech, and short stature. Dysmorphic features included a large bulbous nose and variable microretrognathia. Some patients show joint hyperlaxity and dislocations.
PTM
Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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