Mouse Anti-FBXL3 Recombinant Antibody (CBXF-0386) (CBMAB-F0821-CQ)

Name: Mouse Anti-FBXL3 Recombinant Antibody (CBXF-0386)
SKU: CBMAB-F0821-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0386

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

F-box and leucine-rich repeat protein 3

Introduction

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.

Entrez Gene ID

26224

UniProt ID

Q9UKT7

Alternative Names

F-Box And Leucine Rich Repeat Protein 3; F-Box And Leucine-Rich Repeat Protein 3A; F-Box/LRR-Repeat Protein 3A; FBXL3A; FBL3A; F-Box/LRR-Repeat Protein 3; F-Box Protein Fbl3a; FBL3;

Research Area

Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346).

The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346).

Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).

Biological Process

Entrainment of circadian clock by photoperiod Source: UniProtKB
G2/M transition of mitotic cell cycle Source: GO_Central
Protein destabilization Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of circadian rhythm Source: UniProtKB
Rhythmic process Source: UniProtKB-KW
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm. Predominantly nuclear.

Involvement in disease

Intellectual developmental disorder with short stature, facial anomalies, and speech defects (IDDSFAS):
An autosomal recessive disorder characterized by global developmental delay, mildly to severely impaired intellectual development, delayed or slurred speech, and short stature. Dysmorphic features included a large bulbous nose and variable microretrognathia. Some patients show joint hyperlaxity and dislocations.

PTM

Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.

Confino, S., Dor, T., Tovin, A., Wexler, Y., Ben-Moshe Livne, Z., Kolker, M., ... & Gothilf, Y. (2022). A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System. International Journal of Molecular Sciences, 23(4), 2373.

Dai, Y. X., Qiu, M. K., Wang, S. Q., Pan, C., Wang, Y., & Ou, J. M. (2020). lncRNA CASC2 suppresses the growth of hemangioma cells by regulating miR-18a-5p/FBXL3 axis. Journal of Biological Regulators and Homeostatic Agents, 34(1), 49-56.

Ansar, M., Paracha, S. A., Serretti, A., Sarwar, M. T., Khan, J., Ranza, E., ... & Antonarakis, S. E. (2019). Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature. Human molecular genetics, 28(6), 972-979.

Wang, D., Han, X., Li, C., & Bai, W. (2019). FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer. Pathology-Research and Practice, 215(2), 358-365.

Coorey, C., Lal, S., Kutasovic, J., Niland, C., Ferguson, K., Kuo, L. Y., ... & Simpson, P. (2018). Expression of ARGLU and FBXL3 is highly prognostic for invasive lobular carcinoma. Pathology, 50, S68.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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