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Mouse Anti-FBXO31 (AA 269-368) Recombinant Antibody (CBXF-0405) (CBMAB-F0358-CQ)

This product is a mouse antibody that recognizes FBXO31 (AA 269-368). The antibody CBXF-0405 can be used for immunoassay techniques such as: ELISA.
See all FBXO31 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0405
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 269-368

Target

Full Name
F-box protein 31
Introduction
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
79791
UniProt ID
Q5XUX0
Alternative Names
F-Box Protein 31; F-Box Only Protein 31; Fbx31; FBX14; SCF Ubiquitin Ligase Specificity Factor; Putative Breast Cancer Tumor-Suppressor; FBXO14; Pp2386; MRT45;
Research Area
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic G1 DNA damage checkpoint signaling Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: Ensembl
Positive regulation of neuron migration Source: Ensembl
Protein ubiquitination Source: UniProtKB-UniPathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Centrosome; Cytosol; Neuronal cell body; SCF ubiquitin ligase complex
Involvement in disease
Mental retardation, autosomal recessive 45 (MRT45):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips.
PTM
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.

Islam, S., Dutta, P., Sahay, O., Gopalakrishnan, K., Muhury, S. R., Parameshwar, P., ... & Santra, M. K. (2022). Feedback‐regulated transcriptional repression of FBXO31 by c‐Myc triggers ovarian cancer tumorigenesis. International Journal of Cancer, 150(9), 1512-1524.

Zhu, Z., Zheng, Y., He, H., Yang, L., Yang, J., Li, M., ... & Huang, H. (2022). FBXO31 sentisizes CSC‐like cells to cisplatin by promoting ferroptosis and facilitating proteasomal degradation of GPX4 in CCA. Liver International.

Lv, L., chao Wang, S., you Mo, J., lin Huang, K., li Xu, M., & Liu, J. (2022). Effects and mechanisms of FBXO31 on Taxol chemoresistance in esophageal squamous cell carcinoma. Biochemical and Biophysical Research Communications, 586, 129-136.

Liu, J., Zang, Y., Ma, C., Wang, D., Tian, Z., Xu, X., ... & Liu, Z. (2022). Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function. Cell death & disease, 13(3), 1-12.

Feng, Y., Liu, M., Xie, P., Dong, R., & Hao, Z. (2022). FBXO31 suppresses lipogenesis and tumor progression in glioma by promoting ubiquitination and degradation of CD147. Prostaglandins & Other Lipid Mediators, 163, 106667.

Tsai, P. H., Chen, L. Z., Tseng, K. F., Chen, F. Y., & Shen, M. Y. (2022). Apolipoprotein C3-Rich Low-Density Lipoprotein Induces Endothelial Cell Senescence via FBXO31 and Its Inhibition by Sesamol In Vitro and In Vivo. Biomedicines, 10(4), 854.

Duan, S., Moro, L., Qu, R., Simoneschi, D., Cho, H., Jiang, S., ... & Pagano, M. (2021). Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. Cell reports, 37(3), 109870.

Liu, K., Xue, B., Bai, G., & Zhang, W. (2020). F-box protein FBXO31 modulates apoptosis and epithelial-mesenchymal transition of cervical cancer via inactivation of the PI3K/AKT-mediated MDM2/p53 axis. Life sciences, 259, 118277.

He, H., Dai, J., Feng, J., He, Q., Chen, X., Dai, W., ... & Huang, H. (2020). FBXO31 modulates activation of hepatic stellate cells and liver fibrogenesis by promoting ubiquitination of Smad7. Journal of Cellular Biochemistry, 121(8-9), 3711-3719.

Li, B., Hong, P., Zheng, C. C., Dai, W., Chen, W. Y., Yang, Q. S., ... & Cheung, A. L. (2019). Identification of miR-29c and its target FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance: functional validation and clinical significance. Theranostics, 9(6), 1599.

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For research use only. Not intended for any clinical use.

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