FBXO31

Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM

Full Name

F-box protein 31

Research Area

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Biological Process

Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Mitotic G1 DNA damage checkpoint signaling Source: UniProtKB
Positive regulation of dendrite morphogenesis Source: Ensembl
Positive regulation of neuron migration Source: Ensembl
Protein ubiquitination Source: UniProtKB-UniPathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

Cellular Location

Centrosome; Cytosol; Neuronal cell body; SCF ubiquitin ligase complex

Involvement in disease

Mental retardation, autosomal recessive 45 (MRT45):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips.

PTM

Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.