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Recombinant Mouse Anti-FBXO43 Recombinant Antibody (2A10) (CBMAB-XB0449-YC)

Provided herein is a Mouse Recombinant Antibody against F-Box Protein 43. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all FBXO43 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
2A10
Antibody Isotype
IgA, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
CRRGSAKARGSKDVL (Synthetic peptide corresponding to aa 613 to 627 of mouse EMI-2)
Specificity
Mouse
Antibody Isotype
IgA, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box protein 43
Introduction
Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
Entrez Gene ID
78803
UniProt ID
Q8CDI2
Alternative Names
F-Box Protein 43; Endogenous Meiotic Inhibitor 2; EMI2; Early Mitotic Inhibitor 2; F-Box Only Protein 43; FBX43; ERP1;
Research Area
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
Biological Process
Meiotic cell cycle Source: UniProtKB-KW
Negative regulation of meiotic nuclear division Source: GO_Central
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of mitotic nuclear division Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.2 Publications
Ubiquitinated in response to calcium, which promotes proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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