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Mouse Anti-FBXO43 Recombinant Antibody (4B6) (CBMAB-A2893-LY)

The product is antibody recognizes FBXO43. The antibody 4B6 immunoassay techniques such as: WB, ELISA.
See all FBXO43 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FBXO43 (XP_209918, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-box protein 43
Introduction
Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM
Entrez Gene ID
286151
UniProt ID
Q4G163
Alternative Names
EMI2; ERP1; Fbx43
Research Area
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
Biological Process
Meiotic cell cycle Source: UniProtKB-KW
Negative regulation of meiotic nuclear division Source: GO_Central
Protein ubiquitination Source: UniProtKB-UniPathway
Regulation of mitotic nuclear division Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.2 Publications
Ubiquitinated in response to calcium, which promotes proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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