Mouse Anti-FCER1A Recombinant Antibody (CBT4088) (V2LY-0625-LY921)

Name: Mouse Anti-FCER1A Recombinant Antibody (CBT4088)
SKU: V2LY-0625-LY921
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-FCER1A Recombinant Antibody (CBT4088) (V2LY-0625-LY921) in WB

Mouse Anti-FCER1A Recombinant Antibody (CBT4088) (V2LY-0625-LY921) in FC

Mouse Anti-FCER1A Recombinant Antibody (CBT4088) (V2LY-0625-LY921) in ELISA

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4088

Application

WB, FC

Immunogen

Purified recombinant fragment of human FCER1A (AA:42-103) expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgE Receptor Ia

Entrez Gene ID

2205

UniProt ID

P12319

Research Area

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Regulation of immune response Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 26-205
Helical: 206-224
Cytoplasmic: 225-257

Tang, R. Y., Yin, L., Yao, L., & Chen, X. P. (2022). An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcεRIα expression. bioRxiv.

Romantowski, J., Maciejewska, A., Polanska, J., Wasilewska, E., Specjalski, K., Chełminska, M., ... & Niedoszytko, M. (2021). IFNG, FCER1A, PCDHB10 expression as a new potential marker of efficacy in grass pollen allergen-specific immunotherapy. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 38(4), 665.

Andiappan, A. K., Puan, K. J., Lee, B., Yeow, P. T., Yusof, N., Merid, S. K., ... & Rotzschke, O. (2021). Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells. Journal of Allergy and Clinical Immunology, 147(4), 1510-1513.

Potaczek, D. P., Przytulska-Szczerbik, A., Bazan-Socha, S., Nastałek, M., Wojas-Pelc, A., Okumura, K., ... & Wypasek, E. (2020). Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human Immunology, 81(12), 709-713.

Homma, T., Yokoyama, K., Itoh, F., Sakamoto, T., Yamagishi, M., Ra, C., ... & Inada, Y. (2020). Evaluation of the high affinity IgE receptor alpha-IgG1 Fc fusion protein (FCER1A-Fc) as a topical ocular anti-allergic agent. Journal of Allergy and Clinical Immunology, 145(2), AB162.

Wei, L., Pavlovic, V., Bansal, A. T., Chen, X., Foster, G. R., He, H., ... & Wat, C. (2019). Genetic variation in FCER1A predicts peginterferon alfa‐2a‐induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B. Journal of Viral Hepatitis, 26(9), 1040-1049.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FCER1A Matched Antibody Pair (415) (CAT#: APMAB-415LY)

FCER1A Matched Antibody Pair (416) (CAT#: APMAB-416LY)

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Armenian Hamster Anti-FCER1A Recombinant Antibody (CBXF-0438) (CAT#: V2LY-0925-LY565)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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