FCER1A
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Full Name
Fc Fragment Of IgE Receptor Ia
Research Area
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Regulation of immune response Source: GO_Central
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 26-205
Helical: 206-224
Cytoplasmic: 225-257
Helical: 206-224
Cytoplasmic: 225-257
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Anti-FCER1A antibodies
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CompareTarget: FCER1A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C1
Application*: E, F, IF, IP, WB
Target: FCER1A
Sensitivity: 0.0016 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: FCER1A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-204
Tag: hFc Tag
Target: FCER1A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-205
Tag: hFc & AVI Tag
Target: FCER1A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-205
Tag: His Tag
Target: FCER1A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-205
Tag: His Tag
Target: FCER1A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-205
Target: FCER1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0441
Application*: F, IF, B
Target: FCER1A
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-0438
Application*: IH, IP, F
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2580
Application*: B
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3512
Application*: WB, F, E, IF, IP, P
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4088
Application*: WB, F
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2420
Application*: WB, F
Target: FCER1A
Specificity: Human
Target: FCER1A
Specificity: Human
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0440
Application*: E, WB
Target: FCER1A
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-2393
Application*: F
Target: FCER1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3724
Application*: IF, F
Target: FCER1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 37
Application*: WB, IP, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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