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Mouse Anti-FCER1A Recombinant Antibody (CBXF-0439) (CBMAB-F2258-CQ)

This product is a mouse antibody that recognizes FCER1A. The antibody CBXF-0439 can be used for immunoassay techniques such as: ELISA, IP.
See all FCER1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0439
Antibody Isotype
IgG
Application
ELISA, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc Fragment Of IgE Receptor Ia
Introduction
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
Entrez Gene ID
2205
UniProt ID
P12319
Alternative Names
Fc Fragment Of IgE Receptor Ia; Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide; IgE Fc Receptor Subunit Alpha; Fc Epsilon Receptor Ia; Fc-Epsilon RI-Alpha; FCE1A; FcERI;
Research Area
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 26-205
Helical: 206-224
Cytoplasmic: 225-257

Tang, R. Y., Yin, L., Yao, L., & Chen, X. P. (2022). An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcεRIα expression. bioRxiv.

Romantowski, J., Maciejewska, A., Polanska, J., Wasilewska, E., Specjalski, K., Chełminska, M., ... & Niedoszytko, M. (2021). IFNG, FCER1A, PCDHB10 expression as a new potential marker of efficacy in grass pollen allergen-specific immunotherapy. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 38(4), 665.

Andiappan, A. K., Puan, K. J., Lee, B., Yeow, P. T., Yusof, N., Merid, S. K., ... & Rotzschke, O. (2021). Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells. Journal of Allergy and Clinical Immunology, 147(4), 1510-1513.

Potaczek, D. P., Przytulska-Szczerbik, A., Bazan-Socha, S., Nastałek, M., Wojas-Pelc, A., Okumura, K., ... & Wypasek, E. (2020). Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human Immunology, 81(12), 709-713.

Homma, T., Yokoyama, K., Itoh, F., Sakamoto, T., Yamagishi, M., Ra, C., ... & Inada, Y. (2020). Evaluation of the high affinity IgE receptor alpha-IgG1 Fc fusion protein (FCER1A-Fc) as a topical ocular anti-allergic agent. Journal of Allergy and Clinical Immunology, 145(2), AB162.

Wei, L., Pavlovic, V., Bansal, A. T., Chen, X., Foster, G. R., He, H., ... & Wat, C. (2019). Genetic variation in FCER1A predicts peginterferon alfa‐2a‐induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B. Journal of Viral Hepatitis, 26(9), 1040-1049.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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