Mouse Anti-FCGR1A Recombinant Antibody (CBXF-3681) (CBMAB-F2776-CQ)

Name: Mouse Anti-FCGR1A Recombinant Antibody (CBXF-3681)
SKU: CBMAB-F2776-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3681

Application

WB, IHC, IF, IHC-P

Immunogen

Full length human recombinant protein of human FCGR1A (NP_000557)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgG Receptor Ia

Introduction

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.

Entrez Gene ID

2209

UniProt ID

P12314

Alternative Names

Fc Fragment Of IgG Receptor Ia; Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64); Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64); Fc Gamma Receptor Ia; IgG Fc Receptor I; Fc-Gamma RIA; Fc-Gamma RI; FcgammaRIa; IGFR1;

Research Area

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Regulation of immune response Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Cell membrane. Stabilized at the cell membrane through interaction with FCER1G.

Topology

Extracellular: 16-292
Helical: 293-313
Cytoplasmic: 314-374

PTM

Phosphorylated on serine residues.

Wu, J., Li, Y., Rendahl, A., & Bhargava, M. (2022). Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis. Frontiers in immunology, 13, 841099.

Reddy, J. S., Wang, X., Allen, M., Carrasquillo, M. M., Biernacka, J. M., Jenkins, G. D., ... & Younkin, S. G. (2022). Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer's disease. medRxiv.

Xu, J. L., & Guo, Y. (2020). FCGR1A serves as a novel biomarker and correlates with immune infiltration in four cancer types. Frontiers in molecular biosciences, 7, 581615.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

FCGR1A Matched Antibody Pair (418) (CAT#: APMAB-418LY)

FCGR1A Matched Antibody Pair (419) (CAT#: APMAB-419LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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