Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-FCN2 Recombinant Antibody (CBXF-2934) (CBMAB-F3641-CQ)


See all FCN2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2934
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
NS0-derived rhFicolin-2
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS, 5% trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ficolin 2
Introduction
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
2220
UniProt ID
Q15485
Alternative Names
Ficolin 2; Collagen/Fibrinogen Domain-Containing Protein 2; Serum Lectin P35; L-Ficolin; 37 KDa Elastin-Binding Protein; Ficolin-Beta; Ficolin B; Hucolin; EBP-37;
Research Area
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
Biological Process
Complement activation, lectin pathway Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Opsonization Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Cellular Location
Secreted
More Infomation

Giraudi, P. J., Salvoza, N., Bonazza, D., Saitta, C., Lombardo, D., Casagranda, B., ... & Rosso, N. (2022). Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. International journal of molecular sciences, 23(5), 2813.

Kamal, S. T., Farres, M. N., Ibrahim, R. A., Ibrahim, I. S., & Ahmed, F. A. (2021). Anti-ficolin-2 Antibody: Could it be a Predictor of Proliferative Lupus Nephritis in Lupus Patients?. The Egyptian Journal of Hospital Medicine, 85(2), 3865-3871.

Giang, N. T., Van Tong, H., Nghia, T. H., Hung, H. V., Van Mao, C., Giang, N. T., ... & Toan, N. L. (2020). Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients. International Journal of Infectious Diseases, 95, 253-261.

Jarlhelt, I., Pilely, K., Clausen, J. B., Skjoedt, M. O., Bayarri-Olmos, R., & Garred, P. (2020). Circulating ficolin-2 and ficolin-3 form heterocomplexes. The Journal of Immunology, 204(7), 1919-1928.

Elkoumi, M. A., Emam, A. A., Allah, M. A. N., Sherif, A. H., Abdelaal, N. M., Mosabah, A. A. A., ... & El-Deeb, F. M. (2019). Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study. Lupus, 28(8), 995-1002.

Jalal, P. J., Urbanowicz, R. A., Horncastle, E., Pathak, M., Goddard, C., Saeed, A., ... & Tarr, A. W. (2019). Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses. Journal of Medical Microbiology, 68(4), 642-648.

Elshamaa, M. F., Hamza, H., Abd El Rahman, N., Emam, S., Elghoroury, E. A., Farid, T. M., ... & Abd El-Aziz, D. (2018). Association of ficolin-2 (FCN2) functional polymorphisms and protein levels with rheumatic fever and rheumatic heart disease: relationship with cardiac function. Archives of Medical Science-Atherosclerotic Diseases, 3(1), 142-155.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FCN2 Recombinant Antibody (CBXF-2934)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry