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Mouse Anti-FGL2 Recombinant Antibody (CBXF-3001) (CBMAB-F3707-CQ)

This product is a mouse antibody that recognizes FGL2. The antibody CBXF-3001 can be used for immunoassay techniques such as: ELISA, IHC, IP, WB.
See all FGL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXF-3001
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa24-123 from human FGL2 (NP_006673) with GST tag
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibrinogen Like 2
Introduction
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.
Entrez Gene ID
Human10875
Mouse14190
Rat84586
UniProt ID
HumanQ14314
MouseP12804
RatG3V7P2
Alternative Names
Fibrinogen Like 2; Fibrinogen-Like Protein 2; PT49; Fibrinogen-Like 2; Fibroleukin; T49;
Function
May play a role in physiologic lymphocyte functions at mucosal sites.
Biological Process
Negative regulation of defense response to virus Source: Ensembl
Negative regulation of dendritic cell antigen processing and presentation Source: Ensembl
Negative regulation of macrophage antigen processing and presentation Source: Ensembl
Negative regulation of memory T cell differentiation Source: Ensembl
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl
Cellular Location
Secreted

Shao, W., Huang, Y., Wang, L., Li, P., Jia, Y., & Zhang, J. (2023). Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis. International Immunopharmacology, 114, 109539.

Zhang, S., Rao, G., Heimberger, A., & Li, S. (2022). Fibrinogen-like protein 2: its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors. Cytokine & Growth Factor Reviews.

Pulkka, O. P., Viisanen, L., Tynninen, O., Laaksonen, M., Reichardt, P., Reichardt, A., ... & Joensuu, H. (2022). Fibrinogen‐like protein 2 in gastrointestinal stromal tumour. Journal of cellular and molecular medicine, 26(4), 1083-1094.

Liu, B. Q., Bao, Z. Y., Zhu, J. Y., & Liu, H. (2021). Fibrinogen‑like protein 2 promotes the accumulation of myeloid‑derived suppressor cells in the hepatocellular carcinoma tumor microenvironment. Oncology letters, 21(1), 1-1.

Robineau-Charette, P., Grynspan, D., Benton, S. J., Gaudet, J., Cox, B. J., Vanderhyden, B. C., & Bainbridge, S. A. (2020). Fibrinogen-like protein 2-associated transcriptional and histopathological features of immunological preeclampsia. Hypertension, 76(3), 910-921.

Hu, J., Wang, H., Li, X., Liu, Y., Mi, Y., Kong, H., ... & Wang, X. (2020). Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. Theranostics, 10(21), 9702.

Wu, S., Li, M., Xu, F., Li, G. Q., Han, B. O., He, X. D., ... & Xu, G. L. (2020). Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization. Biomedicine & Pharmacotherapy, 130, 110468.

Latha, K., Yan, J., Yang, Y., Gressot, L. V., Kong, L. Y., Manyam, G., ... & Rao, G. (2019). The role of fibrinogen-like protein 2 on immunosuppression and malignant progression in glioma. JNCI: Journal of the National Cancer Institute, 111(3), 292-300.

Chen, T. J., Ji, M. X., Tao, Z. Q., Fu, Q. Y., Xiong, K., & Cheng, B. (2019). The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury. Clinica Chimica Acta, 489, 53-57.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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