Mouse Anti-FGL2 Recombinant Antibody (CBXF-0648) (CBMAB-F0885-CQ)

Name: Mouse Anti-FGL2 Recombinant Antibody (CBXF-0648)
SKU: CBMAB-F0885-CQ
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-FGL2 Recombinant Antibody (CBXF-0648) (CBMAB-F0885-CQ) in WB

Western blot analyzing proinflammatory cytokines in infected livers at 24 h and 48 h PI, n = 4 per group. ...View More

Li, J., Diao, B., Guo, S., Huang, X., Yang, C., Feng, Z., ... & Wu, Y. (2017). VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. Nature communications, 8(1), 1322.

Mouse Anti-FGL2 Recombinant Antibody (CBXF-0648) (CBMAB-F0885-CQ) in IF

The relationship between BTLA-HVEM and fibrinogen-like protein 2 (FGL2) expression in sections from patients with HBV-related acute-on-chronic liver failure (HBV-ACLF). Immunofluorescence double staining demonstrated that FGL2 expression was observed in CD31+ endothelial cells, CD68+ macrophages, and CK-18+ bile ducts of HBV-ACLF patients. Moreover, BTLA and HVEM were co-expressed with FGL2. The arrows indicate positive cells. The nuclei were stained with DAPI, and the scale bar indicates 20 μm. ...View More

Xu, H., Cao, D., Guo, G., Ruan, Z., Wu, Y., & Chen, Y. (2012). The intrahepatic expression and distribution of BTLA and its ligand HVEM in patients with HBV-related acute-on-chronic liver failure. Diagnostic Pathology, 7(1), 142.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0648

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Recombinant human Fgl2.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibrinogen Like 2

Introduction

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.

Entrez Gene ID

Human	10875
Mouse	14190
Rat	84586

UniProt ID

Human	Q14314
Mouse	P12804
Rat	G3V7P2

Alternative Names

Fibrinogen Like 2; Fibrinogen-Like Protein 2; PT49; Fibrinogen-Like 2; Fibroleukin; T49;

Function

May play a role in physiologic lymphocyte functions at mucosal sites.

Biological Process

Negative regulation of defense response to virus Source: Ensembl
Negative regulation of dendritic cell antigen processing and presentation Source: Ensembl
Negative regulation of macrophage antigen processing and presentation Source: Ensembl
Negative regulation of memory T cell differentiation Source: Ensembl
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl

Cellular Location

Secreted

Shao, W., Huang, Y., Wang, L., Li, P., Jia, Y., & Zhang, J. (2023). Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis. International Immunopharmacology, 114, 109539.

Zhang, S., Rao, G., Heimberger, A., & Li, S. (2022). Fibrinogen-like protein 2: its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors. Cytokine & Growth Factor Reviews.

Pulkka, O. P., Viisanen, L., Tynninen, O., Laaksonen, M., Reichardt, P., Reichardt, A., ... & Joensuu, H. (2022). Fibrinogen‐like protein 2 in gastrointestinal stromal tumour. Journal of cellular and molecular medicine, 26(4), 1083-1094.

Liu, B. Q., Bao, Z. Y., Zhu, J. Y., & Liu, H. (2021). Fibrinogen‑like protein 2 promotes the accumulation of myeloid‑derived suppressor cells in the hepatocellular carcinoma tumor microenvironment. Oncology letters, 21(1), 1-1.

Robineau-Charette, P., Grynspan, D., Benton, S. J., Gaudet, J., Cox, B. J., Vanderhyden, B. C., & Bainbridge, S. A. (2020). Fibrinogen-like protein 2-associated transcriptional and histopathological features of immunological preeclampsia. Hypertension, 76(3), 910-921.

Hu, J., Wang, H., Li, X., Liu, Y., Mi, Y., Kong, H., ... & Wang, X. (2020). Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. Theranostics, 10(21), 9702.

Wu, S., Li, M., Xu, F., Li, G. Q., Han, B. O., He, X. D., ... & Xu, G. L. (2020). Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization. Biomedicine & Pharmacotherapy, 130, 110468.

Latha, K., Yan, J., Yang, Y., Gressot, L. V., Kong, L. Y., Manyam, G., ... & Rao, G. (2019). The role of fibrinogen-like protein 2 on immunosuppression and malignant progression in glioma. JNCI: Journal of the National Cancer Institute, 111(3), 292-300.

Chen, T. J., Ji, M. X., Tao, Z. Q., Fu, Q. Y., Xiong, K., & Cheng, B. (2019). The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury. Clinica Chimica Acta, 489, 53-57.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FGL2 Matched Antibody Pair (442) (CAT#: APMAB-442LY)

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FGL2 Matched Antibody Pair (442) (CAT#: APMAB-442LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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