Rabbit Anti-FHL3 Recombinant Antibody (CBXF-1119) (CBMAB-F0900-CQ)

This product is a rabbit antibody that recognizes FHL3. The antibody CBXF-1119 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all FHL3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

CBXF-1119

Antibody Isotype

IgG

Application

WB, IHC-P, IF

Basic Information

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

four and a half LIM domains 3

Introduction

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	2275
Mouse	14201
Rat	313582

UniProt ID

Human	Q13643
Mouse	Q9R059
Rat	D3ZPF0

Alternative Names

Four And A Half LIM Domains 3; Skeletal Muscle LIM-Protein 2; SLIM-2; FHL-3; SLIM2; Four And A Half LIM Domains Protein 3; LIM-Only Protein FHL3;

Function

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.

Biological Process

Actin cytoskeleton organization Source: GO_Central
Muscle organ development Source: ProtInc

Cellular Location

Cytoplasm; Nucleus

References

Alkobtawi, M., Pla, P., & Monsoro-Burq, A. H. (2021). BMP signaling is enhanced intracellularly by FHL3 controlling WNT-dependent spatiotemporal emergence of the neural crest. Cell Reports, 35(12), 109289.

Cao, G., Li, P., He, X., Jin, M., Li, M., Chen, S., ... & Chen, B. (2021). FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGF β/Smad-Independent Pathways in Gastric Cancer. Frontiers in oncology, 11, 649029.

Li, P., Cao, G., Zhang, Y., Shi, J., Cai, K., Zhen, L., ... & Wu, Y. (2020). FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors. Aging (Albany NY), 12(1), 53.

Nishikawa, M., Sato, K., Nakano, S., Yamakawa, H., Nagase, T., & Ueda, H. (2019). Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL3. Small GTPases, 10(5), 361-366.

Han, S., Cui, C., Wang, Y., He, H., Shen, X., Chen, Y., ... & Yin, H. (2019). FHL3 negatively regulates the differentiation of skeletal muscle satellite cells in chicken. 3 Biotech, 9(6), 1-8.

Han, W., Hu, P., Wu, F., Wang, S., Hu, Y., Li, S., ... & Peng, X. (2019). FHL3 links cell growth and self-renewal by modulating SOX4 in glioma. Cell Death & Differentiation, 26(5), 796-811.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-FHL3 Recombinant Antibody (2C10)

Mouse Anti-FHL3 Recombinant Antibody (CBXF-3026)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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