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Mouse Anti-FLOT2 Recombinant Antibody (CBXF-0748) (CBMAB-F0436-CQ)

This product is a mouse antibody that recognizes FLOT2. The antibody CBXF-0748 can be used for immunoassay techniques such as: IP, WB.
See all FLOT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0748
Antibody Isotype
IgG2a, κ
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Flotillin 2
Introduction
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.
Entrez Gene ID
2319
UniProt ID
Q14254
Alternative Names
Flotillin 2; Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1); Membrane Component Chromosome 17 Surface Marker 1; Flotillin 2 (Epidermal Surface Antigen 1); Epidermal Surface Antigen; M17S1;
Function
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Biological Process
Anterograde dendritic transport Source: Ensembl
Cell adhesion Source: ProtInc
Epidermis development Source: ProtInc
Membrane raft assembly Source: UniProtKB
Negative regulation of amyloid precursor protein catabolic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of establishment of T cell polarity Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Protein localization to plasma membrane Source: UniProtKB
Protein localization to plasma membrane raft Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of myoblast differentiation Source: UniProtKB
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Cellular Location
Cell membrane; Endosome; Caveola; Membrane. Membrane-associated protein of caveolae.
PTM
ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.

Yu, C., Zhang, H., Liu, S., Li, R., Zhao, X., Chen, Y., ... & Shi, W. (2023). Flot2 acts as a novel mediator of podocyte injury in proteinuric kidney disease. International Journal of Biological Sciences, 19(2), 502-520.

Routledge, D., Rogers, S., Ono, Y., Brunt, L., Meniel, V., Tornillo, G., ... & Scholpp, S. (2022). The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer. Elife, 11, e77376.

Xu, H., Yan, X., Zhu, H., Kang, Y., Luo, W., Zhao, J., ... & Ren, C. (2022). TBL1X and Flot2 form a positive feedback loop to promote metastasis in nasopharyngeal carcinoma. International Journal of Biological Sciences, 18(3), 1134.

Qian, C., Wang, Y., Ji, Y., Chen, D., Wang, C., Zhang, G., & Wang, Y. (2022). Neural stem cell‑derived exosomes transfer miR‑124‑3p into cells to inhibit glioma growth by targeting FLOT2. International Journal of Oncology, 61(4), 1-12.

Song, T., Hu, Z., Liu, J., & Huang, W. (2021). FLOT2 upregulation promotes growth and invasion by interacting and stabilizing EphA2 in gliomas. Biochemical and Biophysical Research Communications, 548, 67-73.

Tian, S., Han, G., Lu, L., & Meng, X. (2020). Circ-FOXM1 contributes to cell proliferation, invasion, and glycolysis and represses apoptosis in melanoma by regulating miR-143-3p/FLOT2 axis. World Journal of Surgical Oncology, 18, 1-12.

Ma, D. M., Sun, D., Wang, J., Jin, D. H., Li, Y., & Han, Y. E. (2020). Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression. Eur Rev Med Pharmacol Sci, 24(5), 2616-2624.

Chen, S. H., Liu, X. N., & Peng, Y. (2019). MicroRNA‐351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus. Journal of cellular and molecular medicine, 23(9), 5895-5906.

Wang, Y., Wang, X., Tang, J., Su, X., & Miao, Y. (2019). The study of mechanism of miR-34c-5p targeting FLOT2 to regulate proliferation, migration and invasion of osteosarcoma cells. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 3559-3568.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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