FLOT2

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

Flotillin 2

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Anterograde dendritic transport Source: Ensembl
Cell adhesion Source: ProtInc
Epidermis development Source: ProtInc
Membrane raft assembly Source: UniProtKB
Negative regulation of amyloid precursor protein catabolic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of establishment of T cell polarity Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Protein localization to plasma membrane Source: UniProtKB
Protein localization to plasma membrane raft Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of myoblast differentiation Source: UniProtKB
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl

Cell membrane; Endosome; Caveola; Membrane. Membrane-associated protein of caveolae.

ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.