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Mouse Anti-FMOD Recombinant Antibody (CBXF-2650) (CBMAB-F0167-CQ)

This product is a mouse antibody that recognizes FMOD. The antibody CBXF-2650 can be used for immunoassay techniques such as: ICFC.
See all FMOD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2650
Antibody Isotype
IgG2b
Application
ICFC

Basic Information

Immunogen
NS0-derived recombinant human Fibromodulin/FMOD, Asp75-Ile376, Accession # NP_002014
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibromodulin
Introduction
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
2331
UniProt ID
Q06828
Alternative Names
Fibromodulin; Keratan Sulfate Proteoglycan Fibromodulin; Collagen-Binding 59 KDa Protein; KSPG Fibromodulin; SLRR2E; FM; Fibromodulin Proteoglycan;
Function
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).
Biological Process
Collagen fibril organization Source: Ensembl
Transforming growth factor beta receptor complex assembly Source: ProtInc
Cellular Location
Extracellular matrix
PTM
Binds keratan sulfate chains.

Zheng, Z., Granado, H. S., & Li, C. (2023). Fibromodulin, a Multifunctional Matricellular Modulator. Journal of Dental Research, 102(2), 125-134.

Silva, T., Gomes, C. P., Voigt, D. D., de Souza, R. B., Medeiros, K., Cosentino, N. L., ... & Acero, P. H. C. (2022). Fibromodulin Gene Variants (FMOD) as Potential Biomarkers for Prostate Cancer and Benign Prostatic Hyperplasia. Disease Markers, 2022.

Lee, E. J., Ahmad, S. S., Lim, J. H., Ahmad, K., Shaikh, S., Lee, Y. S., ... & Choi, I. (2021). Interaction of fibromodulin and myostatin to regulate skeletal muscle aging: an opposite regulation in muscle aging, diabetes, and intracellular lipid accumulation. Cells, 10(8), 2083.

Khan, F. U., Owusu-Tieku, N. Y. G., Dai, X., Liu, K., Wu, Y., Tsai, H. I., ... & Huang, L. (2019). Wnt/β-catenin pathway-regulated fibromodulin expression is crucial for breast cancer metastasis and inhibited by aspirin. Frontiers in Pharmacology, 10, 1308.

Shu, C. C., Flannery, C. R., Little, C. B., & Melrose, J. (2019). Catabolism of fibromodulin in developmental rudiment and pathologic articular cartilage demonstrates novel roles for MMP-13 and ADAMTS-4 in C-terminal processing of SLRPs. International Journal of Molecular Sciences, 20(3), 579.

Pourhanifeh, M. H., Mohammadi, R., Noruzi, S., Hosseini, S. A., Fanoudi, S., Mohamadi, Y., ... & Mirzaei, H. (2019). The role of fibromodulin in cancer pathogenesis: implications for diagnosis and therapy. Cancer cell international, 19, 1-9.

Andenæs, K., Lunde, I. G., Mohammadzadeh, N., Dahl, C. P., Aronsen, J. M., Strand, M. E., ... & Tønnessen, T. (2018). The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. PLoS One, 13(7), e0201422.

Al-Qattan, M. M., & Al-Qattan, A. M. (2018). Fibromodulin: structure, physiological functions, and an emphasis on its potential clinical applications in various diseases. J Coll Physicians Surg Pak, 28(10), 783-90.

Ju Lee, E., Tasleem Jan, A., Hassan Baig, M., Ahmad, K., Malik, A., Rabbani, G., ... & Choi, I. (2018). Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte‐like cells. The FASEB Journal, 32(2), 768-781.

Chen, M., Ba, H., Lu, C., Dai, J., & Sun, J. (2018). Glial cell line-derived neurotrophic factor (GDNF) promotes angiogenesis through the demethylation of the fibromodulin (FMOD) promoter in glioblastoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 24, 6137.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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