Mouse Anti-FNBP1 Recombinant Antibody (CBXF-0798) (CBMAB-F1451-CQ)

Name: Mouse Anti-FNBP1 Recombinant Antibody (CBXF-0798)
SKU: CBMAB-F1451-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0798

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Formin Binding Protein 1

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Formin Binding Protein 1

Introduction

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.

Entrez Gene ID

23048

UniProt ID

Q96RU3

Alternative Names

Formin Binding Protein 1; Formin-Binding Protein 17; FBP17; Formin-Binding Protein 1; KIAA0554; HFBP17;

Function

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity).

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

Biological Process

Endocytosis Source: UniProtKB-KW
Signal transduction Source: InterPro

Cellular Location

Cytoskeleton; Lysosome; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle; Clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.

Involvement in disease

A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with KMT2A/MLL1. The relatively low incidence of the KMT2A/MLL1-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.

Wang, Z., Tian, Z., Song, X., & Zhang, J. (2022). Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. BMC immunology, 23(1), 1-15.

Cao, R., Shao, J., Zhang, W., Lin, Y., Huang, Z., & Li, Z. (2021). Silencing long intergenic non-protein coding RNA 00987 inhibits proliferation, migration, and invasion of osteosarcoma cells by sponging miR-376a-5p to regulate FNBP1 expression. Discover Oncology, 12, 1-11.

Yoon, B. K., Hwang, N., Chun, K. H., Lee, Y., Duarte, T. P. M., Kim, J. W., ... & Kim, J. W. (2021). Sp1-induced FNBP1 drives rigorous 3D cell motility in EMT-type gastric cancer cells. International Journal of Molecular Sciences, 22(13), 6784.

Kervarrec, T., Jacques, B. J., Pissaloux, D., Tirode, F., & de la Fouchardière, A. (2021). FNBP1-BRAF fusion in a primary melanoma of the lung. Pathology, 53(6), 785-788.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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