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Mouse Anti-FNBP1 Recombinant Antibody (CBXF-1760) (CBMAB-F3295-CQ)

This product is a mouse antibody that recognizes FNBP1. The antibody CBXF-1760 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FNBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1760
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Formin Binding Protein 1
Introduction
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.
Entrez Gene ID
23048
UniProt ID
Q96RU3
Alternative Names
Formin Binding Protein 1; Formin-Binding Protein 17; FBP17; Formin-Binding Protein 1; KIAA0554; HFBP17;
Function
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity).

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Biological Process
Endocytosis Source: UniProtKB-KW
Signal transduction Source: InterPro
Cellular Location
Cytoskeleton; Lysosome; Cytoplasm; Cell membrane; Cell cortex; Cytoplasmic vesicle; Clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
Involvement in disease
A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with KMT2A/MLL1. The relatively low incidence of the KMT2A/MLL1-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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