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Mouse Anti-FOXD1 Recombinant Antibody (2C10) (CBMAB-A3104-LY)

The product is antibody recognizes FOXD1. The antibody 2C10 immunoassay techniques such as: WB, ELISA.
See all FOXD1 antibodies
Published Data
Fig.1 SiRNA inhibits FOXD1 expression efficiently in human glioma cell lines.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2C10
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
FOXD1 (NP_004463, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
forkhead box D1
Introduction
This intronless gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in tumor formation. [provided by RefSeq]
Entrez Gene ID
2297
UniProt ID
Q16676
Alternative Names
FKHL8; FREAC4
Function
Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity).

Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Axon guidance Source: Ensembl
Cell differentiation Source: GO_Central
Dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
Luteinizing hormone secretion Source: Ensembl
Metanephric capsule development Source: UniProtKB
Metanephric capsule specification Source: UniProtKB
Metanephric nephron development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Nephrogenic mesenchyme development Source: Ensembl
Positive regulation of BMP signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of kidney development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Ma, Y., Han, J., & Luo, X. (2023). FOXD1‐AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression. Oral Diseases, 29(2), 604-614.

Wu, Q., Ma, J., Wei, J., Meng, W., Wang, Y., & Shi, M. (2021). FOXD1‐AS1 regulates FOXD1 translation and promotes gastric cancer progression and chemoresistance by activating the PI3K/AKT/mTOR pathway. Molecular oncology, 15(1), 299-316.

Gao, Y. F., Liu, J. Y., Mao, X. Y., He, Z. W., Zhu, T., Wang, Z. B., ... & Liu, Z. Q. (2020). LncRNA FOXD1‐AS1 acts as a potential oncogenic biomarker in glioma. CNS Neuroscience & Therapeutics, 26(1), 66-75.

Chen, C., Xu, Z. Q., Zong, Y. P., Ou, B. C., Shen, X. H., Feng, H., ... & Lu, A. G. (2019). CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer. Cell death & disease, 10(3), 178.

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F. X., ... & Liu, G. H. (2019). Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS biology, 17(4), e3000201.

Li, C. H., Chang, Y. C., Hsiao, M., & Liang, S. M. (2019). FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness. Cancers, 11(12), 1897.

Quintero-Ronderos, P., & Laissue, P. (2018). The multisystemic functions of FOXD1 in development and disease. Journal of Molecular Medicine, 96, 725-739.

Li, D., Fan, S., Yu, F., Zhu, X., Song, Y., Ye, M., ... & Lv, Z. (2018). FOXD1 promotes cell growth and metastasis by activation of vimentin in NSCLC. Cellular physiology and biochemistry, 51(6), 2716-2731.

Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K. J., Nemani, N., Natarajaseenivasan, K., ... & Madesh, M. (2018). FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Nature communications, 9(1), 3449.

Tao, J., Cong, H., Wang, H., Zhang, D., Liu, C., Chu, H., ... & Wang, K. (2018). MiR-30a-5p inhibits osteosarcoma cell proliferation and migration by targeting FOXD1. Biochemical and Biophysical Research Communications, 503(2), 1092-1097.

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For research use only. Not intended for any clinical use.

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